Yulizal O K, Tarigan Setia Budi, Isnainul O K, Muttaqin Zainul
Department of Internal Medicine, Faculty of Medicine, Universitas Prima Indonesia, Medan, Indonesia.
Faculty of Medicine, Universitas Prima Indonesia, Medan, Indonesia.
J Adv Vet Anim Res. 2021 Mar 9;8(1):158-163. doi: 10.5455/javar.2021.h498. eCollection 2021 Mar.
This research work aimed to assess the histopathological features and degree of gastritis severity in a rat model, induced by infection after administering omeprazole, amoxicillin, and clarithromycin as the standard first-line eradication regimen.
Twenty-one male rats were adapted for 7 days and randomly divided into three equal groups. Group 1 was considered a negative control. Group 2 and Group 3 were treated as -inoculated groups. Group 2 was set as a positive control. Group 3 was administered omeprazole, amoxicillin, and clarithromycin as a first-line eradication regimen. Gastric histopathological examination was conducted. The difference in the severity of gastritis among the groups was examined using the one-way analysis of variance test. The significance was determined to be < 0.05.
Gastritis was found in all inoculated groups. The severity of gastritis was highest in Group 2 ( < 0.05). We could see a refinement in gastritis severity after administering omeprazole, amoxicillin, and clarithromycin as a first-line eradication regimen (Group 3 Group 2; <0.05).
Gastritis, induced by the rat model, was found in all inoculated groups. There was a refinement in the degree of gastritis severity after the administration of omeprazole, amoxicillin, and clarithromycin as a first-line eradication regimen.
本研究旨在评估在给予奥美拉唑、阿莫西林和克拉霉素作为标准一线根除方案后感染诱导的大鼠模型中的组织病理学特征和胃炎严重程度。
21只雄性大鼠适应7天，随机分为三组，每组数量相等。第1组为阴性对照。第2组和第3组为接种组。第2组为阳性对照。第3组给予奥美拉唑、阿莫西林和克拉霉素作为一线根除方案。进行胃组织病理学检查。使用单因素方差分析检验各组胃炎严重程度的差异。显著性水平设定为<0.05。
在所有接种组中均发现胃炎。第2组胃炎严重程度最高（<0.05）。在给予奥美拉唑、阿莫西林和克拉霉素作为一线根除方案后，胃炎严重程度有所改善（第3组<第2组；<0.05）。
在所有接种组中均发现由大鼠模型诱导的胃炎。在给予奥美拉唑、阿莫西林和克拉霉素作为一线根除方案后，胃炎严重程度有所改善。
