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韩国抗反流手术与质子泵抑制剂治疗的比较特征:一项利用2007年至2016年理赔数据的全国性研究。

The characteristics of antireflux surgery compared to proton pump inhibitor treatment in Korea: a nationwide study using claim data from 2007 to 2016.

作者信息

Park Susan, Kwon Jin-Won, Park Joong-Min, Park Sungsoo, Hwang Jinseub, Seo Kyung Won

机构信息

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, Korea.

Department of Surgery, Chung-Ang University College of Medicine, Seoul, Korea.

出版信息

Ann Surg Treat Res. 2020 May;98(5):254-261. doi: 10.4174/astr.2020.98.5.254. Epub 2020 Apr 28.

DOI:10.4174/astr.2020.98.5.254
PMID:32411630
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7200601/
Abstract

PURPOSE

Laparoscopic antireflux surgery is not widely used in Korea, but published data suggest that its results are comparable to those of Western countries. The purpose of this study was to compare the clinical characteristics, medical utilization, and medical costs of antireflux surgery and proton pump inhibitor (PPI) treatments.

METHODS

We used Korean patients who underwent fundoplication (n = 342, surgery group) and a 25% random sample of all patients diagnosed with gastroesophageal reflux disease (GERD) who were prescribed PPIs for more than 12 weeks (n = 130,987, medication group) between 2007 to 2016. We compared medical costs and utilization between the 2 groups.

RESULTS

The average cost of fundoplication was $4,631. The costs of GERD treatment in the first year after surgery and during the follow-up period were $78.1 and $50.1 per month, respectively. In the surgery group, the average monthly medical expenses decreased as the year progressed, but the average monthly medical expenses ($137.5 per month) did not decrease in the medication group. After stratifying by age group, the medical costs of the surgery group were lower than those of the medication group for all ages except for patients between the ages of 70 and 79. The cost difference between the 2 groups was prominent between the ages of 20 and 49.

CONCLUSION

This study showed that a significant decrease in cost was observed 1 year after surgery, and it was more apparent in younger patients. Further research is needed to determine the appropriateness of antireflux surgery for each group of patients.

摘要

目的

腹腔镜抗反流手术在韩国并未广泛应用,但已发表的数据表明其结果与西方国家相当。本研究的目的是比较抗反流手术与质子泵抑制剂(PPI)治疗的临床特征、医疗利用情况和医疗成本。

方法

我们纳入了2007年至2016年间接受胃底折叠术的韩国患者(n = 342,手术组)以及所有被诊断为胃食管反流病(GERD)且接受PPI治疗超过12周的患者的25%随机样本(n = 130,987,药物治疗组)。我们比较了两组之间的医疗成本和利用情况。

结果

胃底折叠术的平均成本为4631美元。手术后第一年和随访期间GERD治疗的成本分别为每月78.1美元和50.1美元。在手术组中,平均每月医疗费用随着时间推移而下降,但在药物治疗组中平均每月医疗费用(每月137.5美元)并未下降。按年龄组分层后,除70至79岁的患者外,手术组在所有年龄段的医疗成本均低于药物治疗组。两组之间的成本差异在20至49岁之间最为显著。

结论

本研究表明,手术后1年成本显著下降,且在年轻患者中更为明显。需要进一步研究以确定抗反流手术对每组患者的适用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4614/7200601/f1e72dad7ef1/astr-98-254-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4614/7200601/f1e72dad7ef1/astr-98-254-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4614/7200601/f1e72dad7ef1/astr-98-254-g001.jpg

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2
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J Neurogastroenterol Motil. 2019 Jul 1;25(3):394-402. doi: 10.5056/jnm19059.
3
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胃食管反流病的当前管理——治疗成本、安全性和有效性:一项叙述性综述
Gastroenterol Rep (Oxf). 2023 Apr 18;11:goad008. doi: 10.1093/gastro/goad008. eCollection 2023.
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Advantages and Disadvantages of Long-term Proton Pump Inhibitor Use.长期使用质子泵抑制剂的利弊
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