Fetkovska N, Amstein R, Ferracin F, Bühler F R, Pletscher A
Department of Medicine, University Hospital, Basle, Switzerland.
J Hypertens Suppl. 1988 Dec;6(4):S646-8. doi: 10.1097/00004872-198812040-00203.
The platelet-activating effect of low-density lipoprotein, ADP and collagen was investigated in 45 essential hypertensive patients (27 men, 18 women) and 45 healthy normotensive subjects strictly matched for age and sex. No differences in mean values were found between essential hypertensive and normotensive subjects. However, in essential hypertensive patients platelet sensitivity to low-density lipoprotein correlated positively whereas ADP and collagen correlated negatively with blood pressure (P less than 0.05). Diminished platelet sensitivity to ADP and collagen may reflect receptor desensitization. The pressure-dependent increase in platelet response to low-density lipoprotein possibly contributes to enhanced thrombo-embolic complications and platelet-mediated vasoconstriction as well as to low-density lipoprotein-related vascular damage in essential hypertension.
在45例原发性高血压患者（27例男性，18例女性）和45例年龄及性别严格匹配的健康血压正常受试者中，研究了低密度脂蛋白、二磷酸腺苷（ADP）和胶原蛋白对血小板的激活作用。原发性高血压患者与血压正常受试者的平均值无差异。然而，在原发性高血压患者中，血小板对低密度脂蛋白的敏感性呈正相关，而ADP和胶原蛋白与血压呈负相关（P<0.05）。血小板对ADP和胶原蛋白敏感性降低可能反映了受体脱敏。原发性高血压患者中血小板对低密度脂蛋白反应的压力依赖性增加可能导致血栓栓塞并发症增加、血小板介导的血管收缩以及与低密度脂蛋白相关的血管损伤。
