Division of Biostatistics, University of Minnesota, Minneapolis, Minnesota.
Humphrey School of Public Affairs, University of Minnesota, Minneapolis, Minnesota.
Biometrics. 2021 Jun;77(2):401-412. doi: 10.1111/biom.13294. Epub 2020 Jun 4.
Researchers are increasingly interested in using sensor technology to collect accurate activity information and make individualized inference about treatments, exposures, and policies. How to optimally combine population data with data from an individual remains an open question. Multisource exchangeability models (MEMs) are a Bayesian approach for increasing precision by combining potentially heterogeneous supplemental data sources into analysis of a primary source. MEMs are a potentially powerful tool for individualized inference but can integrate only a few sources; their model space grows exponentially, making them intractable for high-dimensional applications. We propose iterated MEMs (iMEMs), which identify a subset of the most exchangeable sources prior to fitting a MEM model. iMEM complexity scales linearly with the number of sources, and iMEMs greatly increase precision while maintaining desirable asymptotic and small sample properties. We apply iMEMs to individual-level behavior and emotion data from a smartphone app and show that they achieve individualized inference with up to 99% efficiency gain relative to standard analyses that do not borrow information.
研究人员越来越有兴趣利用传感器技术来收集准确的活动信息,并对治疗方法、暴露情况和政策进行个性化推断。如何将群体数据与个体数据最优地结合起来仍然是一个悬而未决的问题。多源可交换性模型(MEMs)是一种贝叶斯方法,通过将潜在异构的补充数据源结合到主要数据源的分析中,以提高精度。MEMs 是一种用于个性化推断的潜在强大工具,但只能整合少数几个来源;它们的模型空间呈指数级增长,使得它们在高维应用中难以处理。我们提出了迭代 MEMs(iMEMs),它在拟合 MEM 模型之前先确定一组最可交换的来源。iMEM 的复杂性与源的数量呈线性关系,iMEMs 在保持理想的渐近和小样本性质的同时,大大提高了精度。我们将 iMEMs 应用于智能手机应用程序中的个体行为和情绪数据,并表明它们可以实现高达 99%的效率增益的个性化推断,相对于不借用信息的标准分析。