CIBER-EHD, Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, Granada, 18071, Spain.
Instituto de Investigación Biosanitaria de Granada (ibs. 18014 GRANADA), Granada, 18014, Spain.
Mol Nutr Food Res. 2020 Jul;64(13):e2000005. doi: 10.1002/mnfr.202000005. Epub 2020 Jun 2.
Obesity is characterized by a dysfunction in the adipose tissue and an inflammatory subclinical state leading to insulin resistance and increased risk of cardiovascular diseases. It is also associated with intestinal dysbiosis that contributes to inflammation development. Lippia citriodora (LCE) contains high levels of polyphenolpropanoids and has shown promising results in obesity. The aim of this study is to investigate a well-characterized extract of LCE in a model of metabolic syndrome in mice, focusing on its effects on metabolic tissues, endothelial dysfunction, and microbiome.
Mice are fed a high fat diet (HFD) for six weeks and treated daily with LCE (1, 10, and 25 mg kg ). Glucose and lipid metabolism is investigated. The inflammatory state in the metabolic tissues and the intestinal microbiota composition are characterized, as well as the endothelium-dependent vasodilator response to acetylcholine.
LCE reduces fat accumulation and improves plasma glycemic and lipid profiles, as well as the inflammatory process and vascular dysfunction. Moreover, LCE lessens intestinal dysbiosis, as it reduces the Firmicutes/Bacteroidetes ratio and increases Akkermansia abundance in comparison with untreated HFD mice.
The antiobesity therapeutic properties of LCE are most probably mediated by the synergic effects of its bioactive compounds.
肥胖的特征是脂肪组织功能障碍和亚临床炎症状态，导致胰岛素抵抗和心血管疾病风险增加。它还与肠道菌群失调有关，后者有助于炎症的发展。莱莉（Lippia citriodora）含有高水平的多酚类物质，在肥胖症方面显示出有希望的结果。本研究旨在研究一种代谢综合征小鼠模型中经过良好表征的莱莉提取物，重点研究其对代谢组织、内皮功能障碍和微生物组的影响。
小鼠喂食高脂肪饮食（HFD）六周，并每天用 LCE（1、10 和 25 mg kg）治疗。研究葡萄糖和脂质代谢。对代谢组织中的炎症状态和肠道微生物群组成以及乙酰胆碱依赖性血管舒张反应进行了特征描述。
LCE 可减少脂肪堆积，改善血浆血糖和血脂谱，并减轻炎症过程和血管功能障碍。此外，与未治疗的 HFD 小鼠相比，LCE 减轻了肠道菌群失调，降低了厚壁菌门/拟杆菌门的比例，增加了阿克曼氏菌的丰度。
LCE 的抗肥胖治疗特性可能是其生物活性化合物的协同作用介导的。
