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可生物降解镁螺钉与钛螺钉治疗移位性肱骨小头骨折的生物力学比较。

Biomechanical comparison of biodegradable magnesium screws and titanium screws for operative stabilization of displaced capitellar fractures.

机构信息

Faculty of Medicine, Department of Orthopedics and Trauma Surgery, Medical Center, Albert Ludwig University of Freiburg, Freiburg, Germany; GERN Gewebeersatz, Regeneration and Neogenese (Tissue Replacement, Regeneration & Neogenesis), Faculty of Medicine, Department of Orthopedics and Trauma Surgery, Medical Center, Albert Ludwig University of Freiburg, Freiburg, Germany.

GERN Gewebeersatz, Regeneration and Neogenese (Tissue Replacement, Regeneration & Neogenesis), Faculty of Medicine, Department of Orthopedics and Trauma Surgery, Medical Center, Albert Ludwig University of Freiburg, Freiburg, Germany.

出版信息

J Shoulder Elbow Surg. 2020 Sep;29(9):1912-1919. doi: 10.1016/j.jse.2020.02.009. Epub 2020 May 13.

Abstract

BACKGROUND

Displaced fractures of the humeral capitellum are commonly treated operatively and fixed by titanium screws (TSs) either directly or indirectly. In the case of direct transcartilaginous fixation, biodegradable screws with the ability to be countersunk can be favorable regarding implant impingement and cartilage destruction. Hence, the goal of this study was to biomechanically compare headless compression screws made from titanium with a biodegradable equivalent made from a magnesium alloy.

METHODS

This biomechanical in vitro study was conducted on 13 pairs of fresh-frozen human cadaveric humeri, in which a standardized Bryan-Morrey type I fracture was fixed using 2 magnesium screws (MSs) or 2 TSs. First, construct stiffness was measured during 10 cycles of static loading between 10 and 50 N. Second, continuous loading was applied at 4 Hz between 10 and 50 N, increasing the maximum load every 10,000 cycles by 25 N until construct failure occurred. This was defined by fragment displacement >3 mm.

RESULTS

Comparison of the 2 screw types showed no differences related to construct stiffness (0.50 ± 0.25 kN/mm in MS group and 0.47 ± 0.13 kN/mm in TS group, P = .701), failure cycle (43,944 ± 21,625 and 41,202 ± 16,457, respectively; P = .701), and load to failure (152 ± 53 N and 150 ± 42 N, respectively; P = .915).

CONCLUSION

Biomechanical comparison showed that simple capitellar fractures are equally stabilized by headless compression screws made from titanium or a biodegradable magnesium alloy. Therefore, in view of the advantages of biodegradable implants for transcartilaginous fracture stabilization, their clinical application should be considered and evaluated.

摘要

背景

肱骨小头骨骨折通常采用手术治疗,并通过钛制螺钉(TS)直接或间接固定。在直接经软骨固定的情况下,可采用能够埋头的可生物降解螺钉,这有利于避免植入物撞击和软骨破坏。因此,本研究的目的是对钛制无头加压螺钉和由镁合金制成的生物可降解等效物进行生物力学比较。

方法

这项生物力学的体外研究在 13 对新鲜冷冻的人体肱骨标本上进行,其中使用 2 个镁螺钉(MS)或 2 个 TS 固定标准化的 Bryan-Morrey Ⅰ型骨折。首先,在 10 至 50 N 的静态加载 10 个循环过程中测量结构刚度。其次,在 10 至 50 N 之间以 4 Hz 的频率连续加载,每 10,000 个循环增加 25 N 的最大载荷,直到结构失效发生。这通过片段位移>3 mm 来定义。

结果

对 2 种螺钉类型的比较显示,在结构刚度(MS 组为 0.50 ± 0.25 kN/mm,TS 组为 0.47 ± 0.13 kN/mm,P =.701)、失效周期(分别为 43,944 ± 21,625 和 41,202 ± 16,457,P =.701)和失效载荷(分别为 152 ± 53 N 和 150 ± 42 N,P =.915)方面均无差异。

结论

生物力学比较表明,钛制无头加压螺钉和生物可降解镁合金制成的螺钉对单纯的肱骨小头骨骨折具有同等的稳定性。因此,鉴于可生物降解植入物在经软骨骨折固定方面的优势,应考虑并评估其临床应用。

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