Fisher R P
Program in Cell Biology and Genetics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021 USA. r-fisher@ski. mskcc.org
Curr Opin Genet Dev. 1997 Feb;7(1):32-8. doi: 10.1016/s0959-437x(97)80106-2.
Understanding of cyclin-dependent kinase (CDK) regulation in mammalian cells has deepened even as the functions ascribed to these enzymes have multiplied. We know from crystallographic studies how a prototypic CDK-cyclin complex is activated and inactivated; the challenge now is to extend this knowledge to other CDKs involved in cell cycle progression. At the same time, as CDKs turn up in some unexpected places, interest in CDK regulation has spread beyond the cell cycle field.
尽管细胞周期蛋白依赖性激酶（CDK）在哺乳动物细胞中的调节作用不断增加，人们对其的理解也日益深入。我们从晶体学研究中了解到典型的CDK-细胞周期蛋白复合物是如何被激活和失活的；现在面临的挑战是将这一知识扩展到参与细胞周期进程的其他CDK。与此同时，由于CDK出现在一些意想不到的地方，对CDK调节的兴趣已经从细胞周期领域扩展开来。
