Department of Population Health, Nutrition and Health Research Group, Luxembourg Institute of Health, Strassen, Luxembourg.
Diabetes & Endocrinology Care Clinique Pédiatrique, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg.
Pediatr Diabetes. 2020 Aug;21(5):758-765. doi: 10.1111/pedi.13055. Epub 2020 Jun 8.
Visceral adipose tissue (VAT) accumulation is a major cardiometabolic risk factor, associated with increased inflammation. Oxidative stress (OS) is also associated with inflammation and cardiometabolic issues, yet mainly through general obesity. Both OS and obesity were linked to vitamin D deficiency.
To investigate whether OS increase is associated with VAT accumulation in youth, and whether in the presence of VAT accumulation, a higher vitamin D status is associated with lower OS.
One hundred and fifty-eight youth with overweight/obesity, 7 to 17 years old, were recruited (Pediatric Clinic, Luxembourg). We assessed visceral and subcutaneous abdominal adipose tissues by magnetic resonance imaging, OS by DNA/RNA oxidative damage with ELISA and vitamin D by high-performance liquid chromatography.
VAT was the body fat compartment the most strongly associated with OS (R : 0.298; P < 10 ). The general linear (GLM) models assessing the relationship between OS, VAT and vitamin D concentrations showed that "Log OS = (0.003 × VAT) + 3.911 (R : 0.083; P-value < 10 )"; "Log OS = (0.003 × VAT) - (0.156 × log vitamin D) + 4.110 (R : 0.101; P-value < 10 )". After back-transformation of the log-values into normal values, the GLM showed that, for a person with an average value of VAT (40.7 cm ), a 10 cm increase in VAT would increase OS by approx. 771.833 pg/mL, after age, gender, Tanner stage and physical activity adjustment. An approximate increase of 9 ng/mL of vitamin D would counterbalance this negative effect of increased VAT.
Dietary strategies improving vitamin D status should be investigated to tackle VAT and OS increase.
内脏脂肪组织（VAT）的堆积是一种主要的代谢心血管风险因素，与炎症增加有关。氧化应激（OS）也与炎症和代谢心血管问题有关，但主要与一般肥胖有关。OS 和肥胖都与维生素 D 缺乏有关。
研究 OS 是否与年轻人的 VAT 堆积有关，以及在存在 VAT 堆积的情况下，较高的维生素 D 状态是否与较低的 OS 有关。
招募了 158 名超重/肥胖的年轻人，年龄 7 至 17 岁（卢森堡儿科诊所）。我们通过磁共振成像评估内脏和皮下腹部脂肪组织，通过 ELISA 评估 OS 由 DNA/RNA 氧化损伤，通过高效液相色谱法评估维生素 D。
VAT 是与 OS 关系最密切的身体脂肪成分（R：0.298；P < 10）。评估 OS、VAT 和维生素 D 浓度之间关系的一般线性（GLM）模型表明，“Log OS =（0.003×VAT）+3.911（R：0.083；P 值 < 10）”；“Log OS =（0.003×VAT）-（0.156×log 维生素 D）+4.110（R：0.101；P 值 < 10）”。在将 log 值转换回正常值后，GLM 显示，对于一个 VAT 平均值为 40.7cm 的人，VAT 增加 10cm 会使 OS 增加约 771.833pg/ml，在年龄、性别、Tanner 阶段和体力活动调整后。维生素 D 增加约 9ng/ml 可以抵消 VAT 增加的这种负面影响。
应研究改善维生素 D 状态的饮食策略，以解决 VAT 和 OS 增加的问题。
