Division of Neurocognitive Disorders, Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.
Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Alzheimers Dement. 2020 Jul;16(7):1013-1022. doi: 10.1002/alz.12108. Epub 2020 May 17.
We examined differences in cortical thickness in empirically derived mild cognitive impairment (MCI) subtypes in the Mayo Clinic Study of Aging.
We compared cortical thickness of four incident MCI subtypes (n = 192) to 1257 cognitive unimpaired individuals.
The subtle cognitive impairment cluster had atrophy in the entorhinal and parahippocampal cortex. The amnestic, dysnomic, and dysexecutive clusters also demonstrated entorhinal cortex atrophy as well as thinning in temporal, parietal, and frontal isocortex in somewhat different patterns.
We found patterns of atrophy in each of the incident MCI clusters that corresponded to their patterns of cognitive impairment. The identification of MCI subtypes based on cognitive and structural features may allow for more efficient trial and study designs. Given individuals in the subtle cognitive impairment cluster have less structural changes and cognitive decline and may represent the earliest group, this could be a unique group to target with early interventions.
我们研究了 Mayo 诊所老龄化研究中经验衍生的轻度认知障碍（MCI）亚型的皮质厚度差异。
我们将 192 例新发 MCI 亚型患者的皮质厚度与 1257 例认知正常个体进行了比较。
轻微认知障碍组的内嗅皮质和海马旁皮质出现萎缩。遗忘型、命名障碍型和执行功能障碍型也表现出内嗅皮质萎缩，以及颞叶、顶叶和额叶等不同区域的大脑皮质变薄。
我们发现，每个新发 MCI 亚组都存在与认知障碍模式相对应的萎缩模式。基于认知和结构特征对 MCI 亚型进行鉴定，可能会使临床试验和研究设计更加有效。鉴于轻微认知障碍组的个体结构变化和认知下降较少，并且可能代表最早的一组，因此这可能是一个独特的群体，可以进行早期干预。
