Department of Endocrinology, Metabolism, Diabetes, & Nutrition, Mayo Clinic, 200 First Street Southwest, Room 5-194 Joseph, Rochester, MN 55905, USA.
Endocrinol Metab Clin North Am. 2020 Jun;49(2):229-237. doi: 10.1016/j.ecl.2020.02.002. Epub 2020 Apr 9.
Although visceral fat is strongly correlated with the metabolic complications of obesity, the existing data indicate it is not the cause of these complications. Excess release of free fatty acids (FFA) from adipose tissue lipolysis can account for a sizable portion of the metabolic complications of obesity. In humans, upper-body subcutaneous adipose tissue accounts for most systemic FFA, whereas visceral fat contributes a modest portion of the excess amount to which the liver is exposed. This pattern is maintained in upper-body/visceral obesity, except that greater amounts of visceral fat expose the liver to more FFA from visceral adipose tissue lipolysis.
虽然内脏脂肪与肥胖的代谢并发症密切相关，但现有数据表明它不是这些并发症的原因。脂肪组织脂解过度释放游离脂肪酸（FFA）可以解释肥胖的代谢并发症的很大一部分。在人类中，上半身皮下脂肪组织占大多数系统性 FFA，而内脏脂肪仅贡献肝脏暴露的多余量的一小部分。这种模式在上半身/内脏肥胖中得以维持，只是更多的内脏脂肪使肝脏暴露于更多来自内脏脂肪组织脂解的 FFA。
