神经性厌食症患者中生长调节素-C和生长激素水平与青春期或青春期后阶段的关系。

Somatomedin-C and growth hormone levels in anorexia nervosa in relation to the puberal or post puberal stages.

Cabranes J A, Almoguera I, Santos J L, Hidalgo I, Borque M M, del Olmo J

Department of Nuclear Medicine and Psychiatry Hospital Universitario San Carlos, Madrid, Spain.

Prog Neuropsychopharmacol Biol Psychiatry. 1988;12(6):865-71. doi: 10.1016/0278-5846(88)90082-6.

Abstract

Plasma concentrations of somatomedin-C and GH were determined in 21 patients diagnosed as anorexia nervosa (AN) and in 44 controls. 2. Somatomedin-C concentrations were significantly lower in pubertal AN patients than in controls, but not in post pubertal patients. 3. GH was increased in both pubertal and post pubertal AN patients, although more in pubertal AN patients. 4. Our results suggest that the hormonal alterations that appear in AN constitute a mechanism of defense against starvation. The activation of these defense mechanisms and the degree of modification produced in normal hormonal patterns depend not only on caloric intake but also on metabolic requirements.

摘要

测定了21例被诊断为神经性厌食症（AN）的患者及44名对照者的血浆生长调节素C和生长激素（GH）浓度。2. 青春期AN患者的生长调节素C浓度显著低于对照组，但青春期后患者则不然。3. 青春期和青春期后AN患者的GH均升高，不过青春期AN患者升高得更多。4. 我们的结果表明，AN中出现的激素改变构成了一种抵御饥饿的机制。这些防御机制的激活以及正常激素模式产生的改变程度不仅取决于热量摄入，还取决于代谢需求。