Instituto de Investigaciones en Comportamiento Alimentario y Nutrición (IICAN), Centro Universitario del Sur, Universidad de Guadalajara, Ciudad Guzmán, Jalisco, México.
Instituto de Investigación en Ciencias Biomédicas (IICB), Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México.
Int J Vitam Nutr Res. 2021 Sep;91(5-6):513-521. doi: 10.1024/0300-9831/a000656. Epub 2020 May 18.
CD36 glycoprotein is a candidate receptor involved in the gustatory detection of lipids and emerging evidence has suggested that genetic variations in may modulate the oral perception threshold to fatty acids. Here, we analyzed the association of -31118 G > A polymorphism in gene with nutritional status and preferences for fatty foods in Mexican children. Genotyping of SNP rs1761667 was performed in school-age children (n = 63) in addition to sensory tests evaluating the preference and satisfaction score assigned to oil-based sauces of different fatty acid composition. The G allele was associated with high BMI z-score in children (OR = 2.43, 95% (CI 1.02-5.99); p = 0.02) but genotypes (AA, GA, and GG) did not show significant association with the preference and satisfaction scores assigned to oil-based sauces. The BMI z-score showed no association with the preference to oil-based sauces; however, children with normal weight gave higher satisfaction scores to sauces with a high content of unsaturated fatty acids than to sauces rich in saturated fatty acids (0.56 ± 1.26 vs. 0.06 ± 1.22; p = 0.02). Therefore, the G allele of -31118 G > A SNP in gene is associated with overweight and obesity in Mexican children but do not appear to modulate the preferences and satisfaction scores to fat.
CD36 糖蛋白是一种参与脂质味觉检测的候选受体，有新的证据表明， 基因中的遗传变异可能调节对脂肪酸的口腔感知阈值。在这里，我们分析了 基因中的-31118 G>A 多态性与墨西哥儿童营养状况和对高脂肪食物偏好的关系。除了评估不同脂肪酸组成的油基酱汁的偏好和满意度评分的感官测试外，还对学龄儿童（n=63）进行了 SNP rs1761667 的基因分型。G 等位基因与儿童高 BMI z 评分相关（OR=2.43，95%（CI 1.02-5.99）；p=0.02），但 基因型（AA、GA 和 GG）与对油基酱汁的偏好和满意度评分无显著相关性。BMI z 评分与对油基酱汁的偏好无关联；然而，体重正常的儿童对富含不饱和脂肪酸的酱汁的满意度评分高于对富含饱和脂肪酸的酱汁（0.56±1.26 对 0.06±1.22；p=0.02）。因此， 基因中的-31118 G>A SNP 的 G 等位基因与墨西哥儿童超重和肥胖有关，但似乎不会调节对脂肪的偏好和满意度评分。
