Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy.
Postgraduate Medical School in Hygiene and Preventive Medicine, University of Messina, Italy.
Acta Biomed. 2020 May 11;91(2):256-273. doi: 10.23750/abm.v91i2.9176.
Healthcare-associated infections (HAIs) are the most frequent and severe complication acquired in healthcare settings with high impact in terms of morbidity, mortality and costs. Many bacteria could be implicated in these infections, but, expecially multidrug resistance bacteria could play an important role. Many microbial typing technologies have been developed until to the the bacterial whole-genome sequencing and the choice of a molecular typing method therefore will depend on the skill level and resources of the laboratory and the aim and scale of the investigation. In several studies the molecular investigation of pathogens involved in HAIs was performed with many microorganisms identified as causative agents such as Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Clostridium difficile, Acinetobacter spp., Enterobacter spp., Enterococcus spp., Staphylococcus aureus and several more minor species. Here, we will describe the most and least frequently reported clonal complex, sequence types and ribotypes with their worldwide geographic distribution for the most important species involved in HAIs.
在医疗机构中获得的与医疗保健相关的感染（HAIs）是最常见和最严重的并发症，在发病率、死亡率和成本方面都有很大的影响。许多细菌都可能与这些感染有关，但特别是多药耐药菌可能会起到重要作用。已经开发了许多微生物分型技术，直到细菌全基因组测序，因此选择分子分型方法将取决于实验室的技能水平和资源以及调查的目的和规模。在一些研究中，对涉及 HAIs 的病原体进行了分子调查，发现了许多被确定为病原体的微生物，如铜绿假单胞菌、大肠杆菌、肺炎克雷伯菌、艰难梭菌、不动杆菌属、肠杆菌属、肠球菌属、金黄色葡萄球菌和其他一些较少的物种。在这里，我们将描述在与 HAIs 相关的最重要的物种中，最常和最少报告的克隆复合体、序列类型和核糖体分型及其全球地理分布。
