Biomedical Photonics Imaging (BMPI), Technical Medical Center, University of Twente, 7522 NH Enschede, The Netherlands.
Translational Liver Research, Medical Cell BioPhysics (MCBP), Technical Medical Center, University of Twente, 7522 NH Enschede, The Netherlands.
Sensors (Basel). 2020 May 14;20(10):2793. doi: 10.3390/s20102793.
Small animals are widely used as disease models in medical research. Noninvasive imaging modalities with functional capability play an important role in studying the disease state and treatment progress. Photoacoustics, being a noninvasive and functional modality, has the potential for small-animal imaging. However, the conventional photoacoustic tomographic systems use pulsed lasers, making it expensive, bulky, and require long acquisition time. In this work, we propose the use of photoacoustic and ultrasound tomographic imaging with LEDs as the light source and acoustic detection using a linear transducer array. We have demonstrated full-view tomographic imaging of a euthanized mouse and a potential application in liver fibrosis research.
小动物被广泛用作医学研究中的疾病模型。具有功能能力的非侵入性成像方式在研究疾病状态和治疗进展方面发挥着重要作用。光声成像是一种非侵入性和功能性的方式，具有小动物成像的潜力。然而，传统的光声层析成像系统使用脉冲激光器，使其昂贵、庞大，并且需要长时间采集。在这项工作中，我们提出使用光声和超声层析成像，以 LED 作为光源，使用线性换能器阵列进行声探测。我们已经证明了对一只安乐死的小鼠进行全视场层析成像，并展示了其在肝纤维化研究中的潜在应用。
