Department of Cancer Immunology and Virology, Dana Farber Cancer Institute, Boston, MA 02215.
Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada; and.
J Immunol. 2020 Jun 1;204(11):2867-2875. doi: 10.4049/jimmunol.2000196.
In the past decade, the study of NK cells was transformed by the discovery of three ways these "innate" immune cells display adaptive immune behavior, including the ability to form long-lasting, Ag-specific memories of a wide variety of immunogens. In this review, we examine these types of NK cell memory, highlighting their unique features and underlying similarities. We explore those similarities in depth, focusing on the role that Ly49 receptors play in various types of NK cell memory. From this Ly49 dependency, we will build a model by which we understand the three types of NK cell memory as aspects of what is ultimately the same adaptive immune process, rather than separate facets of NK cell biology. We hope that a defined model for NK cell memory will empower collaboration between researchers of these three fields to further our understanding of this surprising and clinically promising immune response.
在过去的十年中，NK 细胞的研究发生了转变，人们发现了三种 NK 细胞展示适应性免疫行为的方式，包括形成对各种免疫原的长期、抗原特异性记忆的能力。在这篇综述中，我们研究了这些类型的 NK 细胞记忆，强调了它们独特的特征和潜在的相似性。我们深入探讨了这些相似性，重点关注 Ly49 受体在各种类型的 NK 细胞记忆中的作用。从这种 Ly49 依赖性出发，我们将建立一个模型，通过该模型我们将把三种 NK 细胞记忆理解为同一适应性免疫过程的不同方面，而不是 NK 细胞生物学的不同方面。我们希望 NK 细胞记忆的明确模型将促进这三个领域的研究人员之间的合作，以进一步了解这种令人惊讶且具有临床应用前景的免疫反应。
