大鼠泪液蛋白质的遗传多态性
Genetic polymorphism of tear proteins in the rat.
作者信息
Kondo Y, Hamada S, Serikawa T, Yamada J
机构信息
Institute of Laboratory Animals, Faculty of Medicine, Kyoto University, Japan.
出版信息
Biochem Genet. 1988 Dec;26(11-12):683-91. doi: 10.1007/BF02395515.
Polymorphism of tear proteins was found by agarose gel electrophoresis among inbred strains of rats. The proteins (RTP-1) are inherited as a single autosomoal trait. The locus was designated Rtp-1 (rat tear protein-1) and it had two codominant alleles (Rtp-1a, Rtp-1b). Although we did not find any recombinant between the Rtp-1 and the Mup-1 loci among 67 backcross progeny, we found 3 strains with the recombinant type between them in 33 inbred strains tested. The results suggest that the Rtp-1 locus is very closely linked with the Mup-1 locus, which belongs to rat linkage group II. RTP-1 proteins strongly reacted with anti-MUP-1 A serum on agarose gel electrophoretograms.
通过琼脂糖凝胶电泳在大鼠近交系中发现了泪液蛋白的多态性。这些蛋白质（RTP - 1）作为单一常染色体性状遗传。该基因座被命名为Rtp - 1（大鼠泪液蛋白 - 1），它有两个共显性等位基因（Rtp - 1a、Rtp - 1b）。尽管在67个回交后代中未发现Rtp - 1和Mup - 1基因座之间的任何重组，但在测试的33个近交系中发现了3个具有它们之间重组类型的品系。结果表明，Rtp - 1基因座与属于大鼠连锁群II的Mup - 1基因座紧密连锁。在琼脂糖凝胶电泳图谱上，RTP - 1蛋白与抗MUP - 单克隆抗体A血清强烈反应。
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