大鼠Pg-1（尿胃蛋白酶原-1）基因座的多态性及其连锁分析。

Polymorphism in Pg-1 (urinary pepsinogen-1) locus in the rat and its linkage analysis.

作者信息

Kondo Y, Yamada J

出版信息

Jikken Dobutsu. 1983 Jan;32(1):51-4. doi: 10.1538/expanim1978.32.1_51.

DOI:10.1538/expanim1978.32.1_51

Abstract

Cramer (1981) reported that Pg-1 (urinary pepsinogen) in the rat was loosely linked with albinism in the linkage group I. We performed a three point test on the loci of pg-1, c, and Hbb. We could reconfirm that pg-1 was autosomal trait with two co-dominant alleles of pg-1a and pg-1b. But in progeny of ((WF X IS) X WF) backcross, pg-1 was linked to neither c nor Hbb, while a close linkage between c and Hbb was detected. Also pg-1 was not linked to Mup-1 (LG II), a (LG IV), Es-3 (LG V), and h (LG VI). pg-1 will be one of the most valuable genetic markers of the rats, since pg-1 was highly polymorphic among inbred strains of rats, and not linked to LG I, II, IV, V, and VI.

摘要

克莱默（1981年）报告称，大鼠中的Pg-1（尿胃蛋白酶原）在连锁群I中与白化病存在松散连锁。我们对pg-1、c和Hbb的基因座进行了三点测试。我们可以再次确认pg-1是一种常染色体性状，具有pg-1a和pg-1b两个共显性等位基因。但在（（WF×IS）×WF）回交的后代中，pg-1与c和Hbb均无连锁，而检测到c和Hbb之间存在紧密连锁。此外，pg-1与Mup-1（连锁群II）、a（连锁群IV）、Es-3（连锁群V）和h（连锁群VI）也无连锁。pg-1将成为大鼠最有价值的遗传标记之一，因为pg-1在大鼠近交系中具有高度多态性，且与连锁群I、II、IV、V和VI无连锁。