82 例新型冠状病毒病（COVID-19）患者的人类白细胞抗原等位基因频率分布。
Distribution of HLA allele frequencies in 82 Chinese individuals with coronavirus disease-2019 (COVID-19).
机构信息
HLA Typing Laboratory, Blood Center of Zhejiang Province, Hangzhou, China.
Key Laboratory of Blood Safety Research of Zhejiang Province, Hangzhou, China.
出版信息
HLA. 2020 Aug;96(2):194-196. doi: 10.1111/tan.13941. Epub 2020 Jun 2.
Abstract
COVID-19 is a respiratory disease caused by a novel coronavirus and is currently a global pandemic. HLA variation is associated with COVID-19 because HLA plays a pivotal role in the immune response to pathogens. Here, 82 individuals with COVID-19 were genotyped for HLA-A, -B, -C, -DRB1, -DRB3/4/5, -DQA1, -DQB1, -DPA1, and -DPB1 loci using next-generation sequencing (NGS). Frequencies of the HLA-C07:29, C08:01G, B15:27, B40:06, DRB104:06, and DPB136:01 alleles were higher, while the frequencies of the DRB112:02 and DPB104:01 alleles were lower in COVID-19 patients than in the control population, with uncorrected statistical significance. Only HLA-C07:29 and B15:27 were significant when the corrected P-value was considered. These data suggested that some HLA alleles may be associated with the occurrence of COVID-19.
摘要
COVID-19 是一种由新型冠状病毒引起的呼吸道疾病，目前已在全球范围内流行。HLA 变异与 COVID-19 有关，因为 HLA 在对病原体的免疫反应中起着关键作用。在这里，使用下一代测序（NGS）对 82 名 COVID-19 患者进行了 HLA-A、-B、-C、-DRB1、-DRB3/4/5、-DQA1、-DQB1、-DPA1 和 -DPB1 基因座的基因分型。与对照组相比，COVID-19 患者中 HLA-C07:29、C08:01G、B15:27、B40:06、DRB104:06 和 DPB136:01 等位基因的频率更高，而 DRB112:02 和 DPB104:01 等位基因的频率更低，具有未校正的统计学意义。仅当考虑校正的 P 值时，HLA-C07:29 和 B15:27 才具有统计学意义。这些数据表明，一些 HLA 等位基因可能与 COVID-19 的发生有关。
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