Molina-Solana Pedro, Domínguez-Serrano Francisco de Borja, Garrido-Hermosilla Antonio Manuel, Montero-Iruzubieta Jesús, Fernández-Palacín Ana, Rodríguez-de-la-Rúa-Franch Enrique, Caro-Magdaleno Manuel
Ophthalmology, Virgen Macarena Hospital Seville, Seville, Spain.
Surgery Department, University of Seville, Seville, Spain.
Clin Ophthalmol. 2020 Apr 28;14:1153-1159. doi: 10.2147/OPTH.S248949. eCollection 2020.
Artificial tears only provide transient relief for dry eye. To the best of our knowledge, this is the first study to objectively compare treatment with artificial tears with Keratograph 5M, which allows accurate and objective investigation of dry eye and artificial tear treatment. We aimed to evaluate whether a preservative-free combination of 0.4% hyaluronic acid and 0.2% galactoxyloglucan can improve dry eye using the new topographer, Keratograph 5M.
This prospective longitudinal, single-arm interventional cohort study was performed at a tertiary referral center and involved 20 patients with dry eye (40 eyes). Preservative-free artificial tears were administered every 3 h. The participants underwent clinical and instrumental evaluations at baseline, 15, 30, 60, 90 and 120 min after instillation and 1 week and 1 month after treatment. Baseline values were considered as the controls. All patients were assessed with Keratograph 5M for non-invasive Keratograph first break-up time and non-invasive Keratograph average break-up time, conjunctival hyperemia, and tear meniscus height. Ocular surface staining with fluorescein was evaluated using the slit-lamp and fluorescein break-up time examinations, and the Ocular Surface Disease Index score was recorded for each patient.
The signs and symptoms improved after 1 month of preservative-free 0.4% hyaluronic acid and 0.2% galactoxyloglucan treatment. There was a significant increase in the non-invasive Keratograph first break-up time and non-invasive Keratograph average break-up time at 15, 30, 60, and 90 min, and 1 week and 1 month (P < 0.05) and a decrease in hyperemia, corneal staining, and Ocular Surface Disease Index scores after 1 week and 1 month (P < 0.05). No treatment-related adverse event was observed.
A combination of 0.4% hyaluronic acid and 0.2% galactoxyloglucan artificial tears seems effective for treating dry eye. Keratograph 5M can objectively detect these changes during the follow-up period.
人工泪液仅能为干眼症提供短暂缓解。据我们所知，这是第一项使用角膜地形图仪5M客观比较人工泪液治疗效果的研究，该仪器能够准确、客观地研究干眼症及人工泪液治疗情况。我们旨在评估不含防腐剂的0.4%透明质酸和0.2%半乳甘露聚糖组合使用新型角膜地形图仪角膜地形图仪5M能否改善干眼症。
这项前瞻性纵向单臂干预队列研究在一家三级转诊中心进行，纳入了20例干眼症患者（40只眼）。每3小时给予不含防腐剂的人工泪液。参与者在滴入人工泪液后15、30、60、90和120分钟以及治疗后1周和1个月时接受临床和仪器评估，以基线值作为对照。所有患者均使用角膜地形图仪5M评估无创角膜地形图首次泪膜破裂时间、无创角膜地形图平均泪膜破裂时间、结膜充血和泪河高度。使用裂隙灯和荧光素泪膜破裂时间检查评估荧光素眼表染色情况，并记录每位患者的眼表疾病指数评分。
经过1个月不含防腐剂的0.4%透明质酸和0.2%半乳甘露聚糖治疗后，体征和症状有所改善。在15、30、60和90分钟以及1周和1个月时，无创角膜地形图首次泪膜破裂时间和无创角膜地形图平均泪膜破裂时间显著增加（P < 0.05），1周和1个月后充血、角膜染色和眼表疾病指数评分降低（P < 0.05）。未观察到与治疗相关的不良事件。
0.4%透明质酸和0.2%半乳甘露聚糖组合的人工泪液似乎对治疗干眼症有效。角膜地形图仪5M能够在随访期间客观检测到这些变化。
