Sánchez-González María Carmen, De-Hita-Cantalejo Concepción, Martínez-Lara Concepción, Sánchez-González José-María
Vision Sciences Research Group (CIVIUS), Department of Physics of Condensed Matter, Optics Area, Pharmacy School, University of Seville, Seville, Spain.
Department of Nursing, University Hospital Virgen Macarena, Universidad de Sevilla, Seville, Spain.
Front Med (Lausanne). 2022 Jul 22;9:959165. doi: 10.3389/fmed.2022.959165. eCollection 2022.
The purpose was to assess the efficacy of 0.4% hyaluronic acid and 0.2% galacto-xyloglucan on the subjective symptoms of dry eye disease and invasive and non-invasive tear film signs in oral isotretinoin for acne vulgaris treatment. A prospective, longitudinal, single-blind, clinical study was performed in oral isotretinoin for the acne vulgaris consumer population. Subjective dry eye disease questionnaires and invasive and non-invasive tear film assessments were reported prior to and after 6 weeks of hyaluronic acid with galacto-xyloglucan (HA-GX) treatment vs. hyaluronic acid alone (HA). Participants in the HA-GX group reported a higher decrease in the ocular surface disease index (17.01 ± 11.36 score points) compared to the variation in participants in the HA group (11.61 ± 11.18 score points). Standard patient evaluation of eye dryness also decreased more in participants in the HA-GX group (4.06 ± 5.50 score points) than in participants who received HA alone (0.70 ± 3.16). Regarding non-invasive break-up time (NIBUT), participants in the HA-GX group first NIBUT achieved an increase of 1.75 ± 1.16 s while participants in the HA-alone group demonstrated an increase of only 0.54 ± 1.01 s. The HA-GX group mean NIBUT increased by of 3.72 ± 5.69 s; however, the value for the HA-alone group was 2.19 ± 5.26 s. Hyaluronic acid in combination with galacto-xyloglucan significantly decreased limbal and bulbar conjunctival redness classification and SPEED test outcomes. The inclusion of galacto-xyloglucan also increased BUT and mean NIBUT values compared to those obtained with hyaluronic acid alone.
目的是评估0.4%透明质酸和0.2%半乳甘露聚糖对寻常痤疮口服异维A酸治疗中干眼症主观症状以及侵入性和非侵入性泪膜体征的疗效。对寻常痤疮口服异维A酸的消费人群进行了一项前瞻性、纵向、单盲临床研究。在使用透明质酸联合半乳甘露聚糖（HA-GX）治疗6周前后以及仅使用透明质酸（HA）治疗前后，报告了主观干眼症问卷以及侵入性和非侵入性泪膜评估结果。与HA组参与者的变化（11.61±11.18评分点）相比，HA-GX组参与者报告眼表疾病指数下降幅度更大（17.01±11.36评分点）。HA-GX组参与者的标准干眼患者评估下降幅度（4.06±5.50评分点）也比仅接受HA治疗的参与者（0.70±3.16）更大。关于非侵入性泪膜破裂时间（NIBUT），HA-GX组参与者首次NIBUT增加了1.75±1.16秒，而仅使用HA组参与者仅增加了0.54±1.01秒。HA-GX组平均NIBUT增加了3.72±5.69秒；然而，仅使用HA组的值为2.19±5.26秒。透明质酸联合半乳甘露聚糖显著降低了角膜缘和球结膜充血分级以及SPEED测试结果。与仅使用透明质酸相比，加入半乳甘露聚糖还增加了泪膜破裂时间（BUT）和平均NIBUT值。
