Sánchez-González José-María, De-Hita-Cantalejo Concepción, Martínez-Lara Concepción, Sánchez-González María Carmen
Department of Physics of Condensed Matter, Optics Area, Vision Sciences Research Group (CIVIUS), Pharmacy School, University of Seville, 41012 Seville, Spain.
Department of Nursing, University Hospital Virgen Macarena, University of Seville, 41009 Seville, Spain.
J Clin Med. 2022 Jun 27;11(13):3719. doi: 10.3390/jcm11133719.
To evaluate the stability and permanence of the liquid film created after the instillation of 0.15% crosslinked hyaluronic acid with liposomes and crocin versus the effect of 0.15% standard hyaluronic acid, a prospective, longitudinal, single-blind, single-center study was conducted in symptomatic populations with a novel noninvasive ocular surface analyzer. Limbal and bulbar redness classification, lipid layer thickness, tear meniscus height, and first and mean noninvasive break-up time (FNIBUT and MNIBUT) were performed before and 30 and 45 min after liposome-crosslinked hyaluronic acid (LCHA) and standard hyaluronic acid (HA) eye drop instillations. LCHA had a higher lipid layer thickness than HA (grades 2.00 ± 0.83 and 1.17 ± 0.63 on the Guillon pattern, respectively). LCHA achieved a better tear meniscus height than HA (0.23 ± 0.02 and 0.21 ± 0.02 mm, respectively). LCHA improved FNIBUT and MNIBUT more than HA (for FNIBUT, 6.30 ± 0.94 and 4.77 ± 0.89 s, respectively. For MNIBUT, 17.23 ± 5.11 and 12.41 ± 4.18 s, respectively). Crosslinking hyaluronic acid with liposomes and crocin significantly increases the permanence and stability of the lipid, aqueous, and mucin tear film layers. In a short-term period, liposome and crosslinked hyaluronic acid achieved better first and mean noninvasive break-up times than standard hyaluronic acid.
为了评估滴注含脂质体和藏红花的0.15%交联透明质酸后形成的液膜的稳定性和持久性，并与0.15%标准透明质酸的效果进行对比，我们使用一种新型无创眼表分析仪，对有症状的人群进行了一项前瞻性、纵向、单盲、单中心研究。在滴注脂质体交联透明质酸（LCHA）和标准透明质酸（HA）眼药水之前、之后30分钟和45分钟，分别进行角膜缘和球结膜充血分级、脂质层厚度、泪河高度以及首次和平均无创泪膜破裂时间（FNIBUT和MNIBUT）的测量。LCHA的脂质层厚度高于HA（在Guillon模式下分别为2.00±0.83级和1.17±0.63级）。LCHA的泪河高度比HA更好（分别为0.23±0.02和0.21±0.02毫米）。LCHA对FNIBUT和MNIBUT的改善比HA更大（对于FNIBUT，分别为6.30±0.94和4.77±0.89秒。对于MNIBUT，分别为17.23±约5.11和12.41±4.18秒）。将透明质酸与脂质体和藏红花交联可显著提高脂质、水液和黏蛋白泪膜层的持久性和稳定性。在短期内，脂质体和交联透明质酸比标准透明质酸实现了更好的首次和平均无创泪膜破裂时间。
