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足月出生并母乳喂养婴儿肠道微生物群诱导基因的综合分析

Integrative Analysis of the Genes Induced by the Intestine Microbiota of Infant Born to Term and Breastfed.

作者信息

Nouadi Badreddine, Sbaoui Yousra, El Messal Mariame, Bennis Faiza, Chegdani Fatima

机构信息

Laboratory of Health and Environment, Faculty of Sciences Aïn Chock, Hassan II University of Casablanca, Casablanca, Morocco.

出版信息

Bioinform Biol Insights. 2020 Apr 29;14:1177932220906168. doi: 10.1177/1177932220906168. eCollection 2020.

Abstract

Nowadays, the integration of biological data is a major challenge for bioinformatics. Many studies have examined gene expression in the epithelial tissue in the intestines of infants born to term and breastfed, generating a large amount of data. The integration of these data is important to understand the biological processes involved during bacterial colonization of the newborns intestine, particularly through breast milk. This work aims to exploit the bioinformatics approaches, to provide a new representation and interpretation of the interactions between differentially expressed genes in the host intestine induced by the microbiota.

摘要

如今,生物数据的整合是生物信息学面临的一项重大挑战。许多研究已经检测了足月出生并母乳喂养的婴儿肠道上皮组织中的基因表达,产生了大量数据。整合这些数据对于理解新生儿肠道细菌定植过程中所涉及的生物学过程非常重要,尤其是通过母乳介导的过程。这项工作旨在利用生物信息学方法,为微生物群诱导的宿主肠道中差异表达基因之间的相互作用提供一种新的呈现方式和解释。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe6/7218278/dc5cae5c610a/10.1177_1177932220906168-fig1.jpg

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