Zhao Xixi, Li Hui, Wang Encong, Luo Xiangsheng, Han Chuanliang, Cao Qingjiu, Liu Lu, Chen Jin, Wang Changming, Johnstone Stuart J, Wang Yufeng, Sun Li
The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.
Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.
Front Psychiatry. 2020 May 1;11:348. doi: 10.3389/fpsyt.2020.00348. eCollection 2020.
We investigated working memory (WM) processing in a longitudinal sample of young adults with persistent and remittent childhood-onset ADHD to investigate the neural correlates of working memory with adult outcomes of ADHD.
Forty-seven young Chinese adults who had been diagnosed with ADHD during childhood underwent follow-up assessments for an average of 9 years. The ADHD sample consisted of 25 ADHD persisters (mean age =18.38 ± 0.5 years) and 22 remitters (mean age = 18.78 ± 1.10 years), who were compared with 25 sex ratio- and IQ-matched healthy adults (mean age = 19.60 ± 1.22 years) in a verbal n-back task.
No differences in behavioral measures were observed across the three groups. Compared with the healthy controls, the ADHD persisters and remitters had larger N1 amplitudes and smaller P2 amplitudes, while no significant differences between the persistence and remission groups were observed. The P3 amplitudes of the remission and control groups were higher than that of the persistence group, but there was no significant difference between the remitters and healthy controls.
The P3 amplitudes reflecting postdecisional processing and/or WM updating were sensitive to ADHD remission, as they might improve concurrently with ADHD symptoms. These results indicate that the N1, P2, and P3 components of WM processing might be potential biomarkers for different ADHD outcomes.
我们在一组患有持续性和缓解性儿童期起病的注意力缺陷多动障碍（ADHD）的年轻成年人纵向样本中研究了工作记忆（WM）处理，以探究工作记忆的神经关联与ADHD成人期结局之间的关系。
47名童年期被诊断为ADHD的中国年轻成年人接受了平均9年的随访评估。ADHD样本包括25名持续性ADHD患者（平均年龄=18.38±0.5岁）和22名缓解性患者（平均年龄=18.78±1.10岁），他们在言语n-回溯任务中与25名性别比例和智商匹配健康成年人（平均年龄=19.60±1.22岁）进行比较。
三组在行为指标上未观察到差异。与健康对照组相比，持续性ADHD患者和缓解性患者的N1波幅更大，P2波幅更小，而持续性和缓解性患者组之间未观察到显著差异。缓解性患者组和对照组的P3波幅高于持续性患者组，但缓解性患者和健康对照组之间无显著差异。
反映决策后处理和/或WM更新的P3波幅对ADHD缓解敏感，因为它们可能与ADHD症状同时改善。这些结果表明，WM处理的N1、P2和P3成分可能是不同ADHD结局的潜在生物标志物。
