Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
National Key Clinical Department of Laboratory Medicine, Nanjing, China.
Front Immunol. 2020 Apr 28;11:676. doi: 10.3389/fimmu.2020.00676. eCollection 2020.
Lung cancer is the leading cause of cancer-associated deaths worldwide, with non-small cell-lung cancer (NSCLC) accounting for approximately 80% of cases. Immune escape has been demonstrated to play a key role in the initiation and progression of NSCLC, although the underlying mechanisms are diverse and their puzzling nature is far from being understood. As a critical participant in immune escape, the CD4 T cell subset of regulatory T (Treg) cells, with their immunosuppressive functions, has been implicated in the occurrence of many types of cancers. Additionally, therapies based on Treg blockade have benefited a portion of cancer patients, including those with NSCLC. Accumulating literature has noted high Treg infiltration in NSCLC tumor tissues, bone marrow, lymph nodes and/or blood; moreover, the tumor milieu is involved in regulating the proliferation, differentiation, recruitment and suppressive functions of Treg cells. Multifarious mechanisms by which CD4 Treg cells are generated, attracted and modulated in the NSCLC milieu will be discussed in this review.
肺癌是全球癌症相关死亡的主要原因，其中非小细胞肺癌（NSCLC）约占 80%。免疫逃逸已被证明在 NSCLC 的发生和发展中起关键作用，尽管其潜在机制多种多样，其令人费解的性质还远未被理解。作为免疫逃逸的关键参与者，调节性 T（Treg）细胞的 CD4 T 细胞亚群具有免疫抑制功能，与多种类型的癌症的发生有关。此外，基于 Treg 阻断的治疗方法使包括 NSCLC 患者在内的一部分癌症患者受益。越来越多的文献指出，NSCLC 肿瘤组织、骨髓、淋巴结和/或血液中存在高 Treg 浸润；此外，肿瘤微环境参与调节 Treg 细胞的增殖、分化、募集和抑制功能。本文将讨论 CD4 Treg 细胞在 NSCLC 微环境中产生、吸引和调节的多种机制。
