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Heparin - An old drug with multiple potential targets in Covid-19 therapy.

作者信息

Lindahl Ulf, Li Jin-Ping

机构信息

Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.

出版信息

J Thromb Haemost. 2020 Sep;18(9):2422-2424. doi: 10.1111/jth.14898. Epub 2020 Aug 27.

DOI:10.1111/jth.14898
PMID:32426897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7276884/
Abstract
摘要

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本文引用的文献

1
The Potential of Low Molecular Weight Heparin to Mitigate Cytokine Storm in Severe COVID-19 Patients: A Retrospective Cohort Study.低分子量肝素减轻重症 COVID-19 患者细胞因子风暴的潜力：一项回顾性队列研究。
Clin Transl Sci. 2020 Nov;13(6):1087-1095. doi: 10.1111/cts.12880. Epub 2020 Oct 15.
2
Non-Anticoagulant Heparins as Heparanase Inhibitors.非抗凝肝素作为乙酰肝素酶抑制剂。
Adv Exp Med Biol. 2020;1221:493-522. doi: 10.1007/978-3-030-34521-1_20.
3
The versatile heparin in COVID-19.新冠疫情中用途广泛的肝素。
J Thromb Haemost. 2020 May;18(5):1020-1022. doi: 10.1111/jth.14821. Epub 2020 Apr 27.
4
Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy.抗凝治疗与伴有凝血功能障碍的严重 2019 冠状病毒病患者的死亡率降低相关。
J Thromb Haemost. 2020 May;18(5):1094-1099. doi: 10.1111/jth.14817. Epub 2020 Apr 27.
5
Disseminated intravascular coagulation in patients with 2019-nCoV pneumonia.2019新型冠状病毒肺炎患者的弥散性血管内凝血
J Thromb Haemost. 2020 Apr;18(4):786-787. doi: 10.1111/jth.14781. Epub 2020 Mar 24.
6
Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia.异常的凝血参数与新型冠状病毒肺炎患者的预后不良有关。
J Thromb Haemost. 2020 Apr;18(4):844-847. doi: 10.1111/jth.14768. Epub 2020 Mar 13.
7
The Role of Heparan Sulfate in Inflammation, and the Development of Biomimetics as Anti-Inflammatory Strategies.硫酸乙酰肝素在炎症中的作用，以及仿生学作为抗炎策略的发展。
J Histochem Cytochem. 2018 Apr;66(4):321-336. doi: 10.1369/0022155417740881. Epub 2018 Jan 1.
8
Interactions between heparan sulfate and proteins-design and functional implications.硫酸乙酰肝素与蛋白质之间的相互作用——设计与功能意义
Int Rev Cell Mol Biol. 2009;276:105-59. doi: 10.1016/S1937-6448(09)76003-4.
9
Evidence for a 3-O-sulfated D-glucosamine residue in the antithrombin-binding sequence of heparin.肝素抗凝血酶结合序列中存在3-O-硫酸化D-葡萄糖胺残基的证据。
Proc Natl Acad Sci U S A. 1980 Nov;77(11):6551-5. doi: 10.1073/pnas.77.11.6551.