Graduate School of Biomedical Engineering, University of New South Wales Sydney, Sydney, New South Wales, Australia.
Raymond Purves Bone and Joint Research Laboratory, Kolling Institute, Northern Sydney Local Health District, St. Leonards, New South Wales, Australia.
J Histochem Cytochem. 2018 Apr;66(4):321-336. doi: 10.1369/0022155417740881. Epub 2018 Jan 1.
Key events that occur during inflammation include the recruitment, adhesion, and transmigration of leukocytes from the circulation to the site of inflammation. These events are modulated by chemokines, integrins, and selectins and the interaction of these molecules with glycosaminoglycans, predominantly heparan sulfate (HS). The development of HS/heparin mimetics that interfere or inhibit the interactions that occur between glycosaminoglycans and modulators of inflammation holds great potential for use as anti-inflammatory therapeutics. This review will detail the role of HS in the events that occur during inflammation, their interaction and modulation of inflammatory mediators, and the current advances in the development of HS/heparin mimetics as anti-inflammatory biotherapeutics.
在炎症发生过程中会发生一些关键事件，包括白细胞从血液循环招募、黏附和迁移至炎症部位。这些事件受趋化因子、整合素和选择素的调节，这些分子与糖胺聚糖（主要是肝素硫酸酯（HS））相互作用。开发可干扰或抑制糖胺聚糖与炎症调节剂之间相互作用的 HS/肝素类似物，具有作为抗炎治疗药物的巨大潜力。这篇综述将详细介绍 HS 在炎症发生过程中所发生的作用、它们与炎症介质的相互作用和调节，以及作为抗炎生物治疗药物开发 HS/肝素类似物的最新进展。
