Han Xuan, Ma Shaohua
Department of Thoracic Surgery, Peking University Third Hospital, Beijing 100083, China.
Zhongguo Fei Ai Za Zhi. 2020 May 20;23(5):388-392. doi: 10.3779/j.issn.1009-3419.2020.101.21.
Young adult lung cancer is defined as a group of patients refers to whose onset age is less than 40 years old and ≥18 years old. Compare with elder lung cancer, the clinical symptoms of them are not typical, the stage is usually late at the time of discovery, and most of them have regional lymphatic metastasis or distant metastasis. Current study found that young adult lung cancer has a relatively unique genetic background, the abundance of tumor-driving genes is high, and it is closely related to its clinical manifestation and prognosis. Young adult lung cancer is the focus of attention in the field of cancer in recent years. This article reviewed the literature on the clinical features, gene phenotypic characteristics and prognosis of young adult lung cancer in order to provide provide some references and clues for the study on young adult lung cancer.
青年肺癌被定义为一组发病年龄小于40岁且≥18岁的患者。与老年肺癌相比,其临床症状不典型,发现时分期通常较晚,且大多数有区域淋巴结转移或远处转移。目前的研究发现,青年肺癌有相对独特的基因背景,肿瘤驱动基因丰度高,且与其临床表现及预后密切相关。青年肺癌是近年来癌症领域关注的焦点。本文对青年肺癌的临床特征、基因表型特征及预后的文献进行综述,以便为青年肺癌的研究提供一些参考和线索。