聚（硒代二茂铁）组装上转换纳米粒子用于低功率单近红外光触发协同光动力和光热抗菌治疗。
Poly(selenoviologen)-Assembled Upconversion Nanoparticles for Low-Power Single-NIR Light-Triggered Synergistic Photodynamic and Photothermal Antibacterial Therapy.
机构信息
Frontier Institute of Science and Technology, State Key Laboratory for Strength and Vibration of Mechanical Structures, Xi'an Jiaotong University, Xi'an, Shaanxi Province 710054, China.
Center for Tissue Engineering, School of Stomatology, Fourth Military Medical University, Xi'an, Shaanxi province 710032, China.
出版信息
ACS Appl Mater Interfaces. 2020 Jun 10;12(23):26432-26443. doi: 10.1021/acsami.0c04506. Epub 2020 Jun 1.
The development of a highly effective photosensitizer (PS) that can be activated with a low-power single light is a pressing issue. Herein, we report a PS for synergistic photodynamic and photothermal therapy constructed through self-assembly of poly(selenoviologen) on the surface of core-shell NaYF:Yb/Tm@NaYF upconversion nanoparticles. The hybrid UCNPs/PSeV PS showed strong ROS generation ability and high photothermal conversion efficiency (∼52.5%) under the mildest reported-to-date irradiation conditions (λ = 980 nm, 150 mW/cm, 4 min), leading to a high efficiency in killing methicillin-resistant (MRSA) both and . Remarkably, after intravenous injection, the reported PS accumulated preferentially in deep MRSA-infected tissues and achieved an excellent therapeutic index. This PS design realizes a low-power single-NIR light-triggered synergistic phototherapy and provides a simple and versatile strategy to develop safe clinically translatable agents for efficient treatment of deep tissue bacterial inflammations.
开发一种高效的光动力治疗敏化剂（PS），使其能够在低功率单光的条件下被激活是一个紧迫的问题。在此，我们通过在核壳 NaYF:Yb/Tm@NaYF 上转换纳米粒子的表面自组装聚硒吩（PSeV），报道了一种用于协同光动力和光热治疗的 PS。在迄今为止报道的最温和的照射条件下（λ = 980nm，150mW/cm，4min），该杂化 UCNPs/PSeV PS 表现出了很强的 ROS 生成能力和高光热转换效率（~52.5%），导致对耐甲氧西林金黄色葡萄球菌（MRSA）和 的杀伤效率很高。值得注意的是，静脉注射后，该报道的 PS 优先聚集在深部 MRSA 感染组织中，并实现了优异的治疗指数。该 PS 设计实现了低功率单近红外光触发的协同光疗，并为开发安全的临床可转化的高效治疗深部组织细菌炎症的试剂提供了一种简单而通用的策略。
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