Ningxia Medical University Pharmacy College, Key Laboratory of Hui Ethnic Medicine Modernization, Ministry of Education, Ningxia Research Center of Modern Hui Medicine Engineering and Technology, Yinchuan, P. R. China.
College of Basic Medical Sciences, Jilin University, Changchun, Jilin, P. R. China.
Pharm Biol. 2020 Dec;58(1):410-416. doi: 10.1080/13880209.2020.1758732.
Alzheimer's disease (AD) is a chronic neurodegenerative disease that originates from central nervous system lesions or recessions. Current estimates suggest that this disease affects over 35 million people worldwide. However, lacking effective drugs is the biggest handicap in treating AD. In traditional Chinese medicine (TCM), Willd. (Polygalaceae) is generally used to treat insomnia, memory dysfunction and neurasthenia. This review article explores the role of and its active components in anti-Alzheimer's disease. Literature for the last ten years was obtained through a search on PubMed, SciFinder, CNKI, Google Scholar, Web of Science, Science Direct and China Knowledge Resource Integrated with the following keywords: Polygala tenuifolia, polygalasaponin XXXII (PGS 32), tenuifolin, polygalacic acid, senegenin, tenuigenin, Alzheimer's disease. and its active components have multiplex neuroprotective potential associated with AD, such as anti-A aggregation, anti-Tau protein, anti-inflammation, antioxidant, anti-neuronal apoptosis, enhancing central cholinergic system and promote neuronal proliferation. and its active components exhibit multiple neuroprotective effects. Hence, is a potential drug against Alzheimer's disease, especially in terms of prevention.
阿尔茨海默病（AD）是一种起源于中枢神经系统损伤或衰退的慢性神经退行性疾病。目前估计，这种疾病影响全球超过 3500 万人。然而，缺乏有效的药物是治疗 AD 的最大障碍。在传统中医（TCM）中，远志通常用于治疗失眠、记忆功能障碍和神经衰弱。本文综述探讨了远志及其活性成分在抗阿尔茨海默病中的作用。通过在 PubMed、SciFinder、CNKI、Google Scholar、Web of Science、Science Direct 和中国知识资源全文数据库上搜索，获取了过去十年的文献，使用的关键词为远志、远志皂苷 XXXII（PGS32）、远志酸、远志糖苷元、远志醇、远志酮、阿尔茨海默病。远志及其活性成分具有与 AD 相关的多种神经保护潜能，如抗 A 聚集、抗 Tau 蛋白、抗炎、抗氧化、抗神经元凋亡、增强中枢胆碱能系统和促进神经元增殖。远志及其活性成分具有多种神经保护作用。因此，远志是一种有潜力的治疗阿尔茨海默病的药物，特别是在预防方面。
