1International Outpatient Department of Vietnam National Children's Hospital (VNCH), Hanoi, Vietnam.
2Clinical Medicine of Children Infectious Diseases Centre of Vietnam National Children's Hospital (VNCH), Hanoi, Vietnam.
Am J Trop Med Hyg. 2020 Aug;103(2):723-726. doi: 10.4269/ajtmh.20-0166. Epub 2020 May 14.
Meningoencephalitis is not a rare disease in small children. However, eosinophilic meningitis due to is unusual in a baby. We describe the case of a 9-month-old baby from North Vietnam with eosinophilic meningoencephalitis. The baby lived in a rural area, where farming is widespread, and presented with fever and seizures. Laboratory results showed peripheral eosinophilia (16.1%), cerebrospinal fluid (CSF) white blood cell count 220/mm (26% eosinophils), CSF antibody test positive for , CSF ELISA positive for , and blood ELISA positive for . A mobile worm was identified in the CSF. The presentation was consistent with a diagnosis of eosinophilic meningitis. The baby recovered fully after administering albendazole (200 mg/day for 2 weeks), and intravenous dexamethasone (0.6 mg/kg/day every 8 hours) and mannitol (1.5 g/kg/day every 8 hours) for the first 3 days, followed by 5 days of oral prednisolone (2 mg/kg/day).
脑膜脑炎在幼儿中并不罕见。然而，婴儿患嗜酸性粒细胞性脑膜炎是不常见的。我们描述了来自越南北部的一例 9 个月大的婴儿，患有嗜酸性粒细胞性脑膜脑炎。该婴儿生活在一个广泛从事农业的农村地区，表现出发热和癫痫发作。实验室结果显示外周血嗜酸性粒细胞增多（16.1%），脑脊液（CSF）白细胞计数 220/mm（26%嗜酸性粒细胞），CSF 抗体试验对 阳性，CSF ELISA 对 阳性，血 ELISA 对 阳性。在 CSF 中发现了一条移动的虫体。临床表现符合 嗜酸性粒细胞性脑膜炎的诊断。给予阿苯达唑（200 mg/天，共 2 周）治疗后，婴儿完全康复，前 3 天静脉注射地塞米松（0.6 mg/kg/天，每 8 小时一次）和甘露醇（1.5 g/kg/天，每 8 小时一次），然后口服泼尼松龙 5 天（2 mg/kg/天）。
