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基于 TRB,对兽医物种的 T 细胞受体 β 基因座进行 IMGT® 生物信息学注释和比较研究。

IMGT® Biocuration and Comparative Study of the T Cell Receptor Beta Locus of Veterinary Species Based on TRB.

机构信息

IMGT®, The International ImMunoGeneTics Information System®, Centre National de la Recherche Scientifique (CNRS), Institut de Génétique Humaine (IGH), Université de Montpellier (UM), Montpellier, France.

出版信息

Front Immunol. 2020 May 5;11:821. doi: 10.3389/fimmu.2020.00821. eCollection 2020.

Abstract

IMGT®, the international ImMunoGeneTics information system® is the global reference in immunogenetics and immunoinformatics. By its creation in 1989 by Marie-Paule Lefranc (Université de Montpellier and CNRS), IMGT® marked the advent of immunoinformatics, which emerged at the interface between immunogenetics and bioinformatics. IMGT® is specialized in the immunoglobulins (IG) or antibodies, T cell receptors (TR), major histocompatibility (MH), and proteins of the IgSF and MhSF superfamilies. T cell receptors are divided into two groups, αβ and γδ TR, which express distinct TR containing either α and β, or γ and δ chains, respectively. The TRβ locus (TRB) was recently described and annotated by IMGT® biocurators for several veterinary species, i.e., cat (), dog (), ferret (), pig (), rabbit (), rhesus monkey (), and sheep (). The aim of the present study is to compare the genes of the TRB locus among these different veterinary species based on . The results reveal that there are similarities but also differences including the number of genes by subgroup which may demonstrate duplications and/or deletions during evolution.

摘要

IMGT®,即国际免疫遗传学信息系统®,是免疫遗传学和免疫信息学的全球参考。由 Marie-Paule Lefranc(蒙彼利埃大学和法国国家科学研究中心)于 1989 年创建,IMGT®标志着免疫信息学的出现,它出现在免疫遗传学和生物信息学的接口上。IMGT®专注于免疫球蛋白(IG)或抗体、T 细胞受体(TR)、主要组织相容性(MH)以及 IgSF 和 MhSF 超家族的蛋白质。T 细胞受体分为两组,αβ和γδ TR,分别表达含有α和β或γ和δ链的不同 TR。最近,IMGT®生物注释员对几种兽医物种(即猫、狗、雪貂、猪、兔、恒河猴和绵羊)的 TRβ基因座(TRB)进行了描述和注释。本研究旨在比较这些不同兽医物种中 TRB 基因座的基因,基于。结果表明,存在相似之处,但也存在差异,包括亚组的基因数量,这可能表明在进化过程中发生了重复和/或缺失。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b1b/7216736/47501693210c/fimmu-11-00821-g0001.jpg

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