Henann N E, Carpenter D U, Janda S M
School of Pharmacy, Northeast Louisiana University, Monroe 71209.
Drug Intell Clin Pharm. 1988 Dec;22(12):976-8. doi: 10.1177/106002808802201209.
Central nervous system effects, such as mental confusion and hallucinations, have been reported with both cimetidine and ranitidine. Elderly patients with renal or hepatic dysfunction are more susceptible to these adverse reactions. We report two cases of reversible mental confusion in elderly patients with mild renal insufficiency following intravenous famotidine therapy, possibly explained by an increased permeability of the blood-brain barrier in patients with decreased renal function.
据报道，西咪替丁和雷尼替丁均可产生中枢神经系统效应，如精神错乱和幻觉。肾功能或肝功能不全的老年患者更容易出现这些不良反应。我们报告了两例老年轻度肾功能不全患者在静脉注射法莫替丁治疗后出现可逆性精神错乱的病例，这可能是由于肾功能减退患者血脑屏障通透性增加所致。
