Department of Gastrointestinal Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, PR China.
Epigenomics. 2020 Jun;12(12):989-1002. doi: 10.2217/epi-2020-0114. Epub 2020 May 20.
To identify novel competing endogenous RNA (ceRNA) network correlated with the prognosis of gastric cancer (GC) patients. We systematically analyzed the aberrantly expressed genes in human GC to construct a ceRNA network by using multiple bioinformatic tools. Aberrantly expressed mRNAs in GC were identified. By means of stepwise reverse prediction and validation from mRNA to lncRNA, a ceRNA network comprised of and was constructed, and all genes in the network are significantly correlated with the prognosis of GC patients. The present study successfully constructed a GC related ceRNA network, and provided potential targets for GC clinical treatment.
为了鉴定与胃癌（GC）患者预后相关的新型竞争性内源 RNA（ceRNA）网络。我们系统地分析了人类 GC 中的异常表达基因，通过使用多种生物信息学工具构建了 ceRNA 网络。鉴定了 GC 中的异常表达 mRNA。通过从 mRNA 到 lncRNA 的逐步反向预测和验证，构建了一个由 和 组成的 ceRNA 网络，并且网络中的所有基因都与 GC 患者的预后显著相关。本研究成功构建了一个与 GC 相关的 ceRNA 网络，为 GC 的临床治疗提供了潜在的靶点。
