Thorbecke R
Abteilung für Neurologie, Universitätsklinikum Rudolf-Virchow, Standort Charlottenburg der Freien Universität Berlin, Germany.
Epilepsy Res Suppl. 1988;1:79-83.
In this study different indices for compliance with antiepileptic drug (AED) treatment were derived from a sample of 41 patients with epilepsy, coming for the first time to an out-patient clinic: forgetting a dose, aids for drug intake (e.g., a pill box), tying intake to stable habits, intake at weekends, taking less than prescribed, taking more than prescribed, expected physical harm as a consequence of drug intake. Significant interrelations were found between reporting having thought of discontinuation because of physical harm and actual discontinuation in the past (P = 0.04), between use of an aid and tying intake to stable habits in the morning, at noon and in the evening (P = 0.01, P = 0.03, P = 0.08). There was a relation between using an aid and plasma levels of AEDs (P = 0.03). Finally an index was constructed from the different measures for intake behaviour. There was a correlation r = -0.60 with coefficients of variation for phenytoin, carbamazepine and phenobarbital (P = 0.05).
在本研究中，从41例首次前往门诊就诊的癫痫患者样本中得出了不同的抗癫痫药物（AED）治疗依从性指标：漏服一剂、药物服用辅助工具（如药盒）、将服药与稳定习惯联系起来、周末服药、服用剂量低于规定剂量、服用剂量高于规定剂量、因服药导致的预期身体伤害。在报告因身体伤害而考虑停药与过去实际停药之间发现了显著的相关性（P = 0.04），在使用辅助工具与早上、中午和晚上将服药与稳定习惯联系起来之间也发现了显著相关性（P = 0.01、P = 0.03、P = 0.08）。使用辅助工具与AEDs的血浆水平之间存在关联（P = 0.03）。最后，根据不同的服药行为测量指标构建了一个指数。该指数与苯妥英钠、卡马西平和苯巴比妥的变异系数之间存在相关性r = -0.60（P = 0.05）。
