Stanaway L, Lambie D G, Johnson R H
N Z Med J. 1985 Mar 13;98(774):150-2.
Compliance with anticonvulsant therapy was assessed in 95 epileptic subjects with uncontrolled seizures. Following a seizure for which an ambulance was called, patients were interviewed and questioned on their medication taking. Compliance was also determined from measurement of anticonvulsant concentrations in saliva, and from intervals between collection of drugs from pharmacy. Compliance failure was found to be instrumental in precipitating 29 (31%) of seizures for which the ambulance was called. At the time of interview, 35 (37%) subjects were not taking their medication regularly in accordance with prescribing instructions. In addition to forgetting medication, many subjects deliberately stopped or changed doses of drugs. Other causes of non-compliance which were indentified included patient misunderstanding of prescribing instructions. Compliance with therapy was positively related to perceived benefit from anticonvulsant therapy.
对95名癫痫发作未得到控制的癫痫患者的抗惊厥治疗依从性进行了评估。在一次呼叫救护车的癫痫发作后，对患者进行了访谈并询问其用药情况。还通过测量唾液中的抗惊厥药物浓度以及从药房取药的间隔时间来确定依从性。发现依从性不佳是导致29次（31%）呼叫救护车的癫痫发作的原因。在访谈时，35名（37%）受试者未按照处方说明规律服药。除了忘记服药外，许多受试者还故意停药或改变药物剂量。已确定的其他不依从原因包括患者对处方说明的误解。治疗依从性与抗惊厥治疗的感知益处呈正相关。
