Department of Physiology, Cardiovascular Innovation Institute, University of Louisville, Louisville, Kentucky.
Am J Physiol Cell Physiol. 2020 Jul 1;319(1):C166-C182. doi: 10.1152/ajpcell.00021.2020. Epub 2020 May 20.
This review aims to highlight the normal physiological remodeling that occurs in healthy aging hearts, including changes that occur in contractility, conduction, valve function, large and small coronary vessels, and the extracellular matrix. These "normal" age-related changes serve as the foundation that supports decreased plasticity and limited ability for tissue remodeling during pathophysiological states such as myocardial ischemia and heart failure. This review will identify populations at greater risk for poor tissue remodeling in advanced age along with present and future therapeutic strategies that may ameliorate dysfunctional tissue remodeling in aging hearts.
本综述旨在强调健康衰老心脏中发生的正常生理重塑，包括收缩性、传导、瓣膜功能、大中小冠状动脉以及细胞外基质的变化。这些“正常”的与年龄相关的变化为心肌缺血和心力衰竭等病理生理状态下组织重塑的可塑性降低和能力有限提供了基础。本综述将确定在高龄时组织重塑较差风险较高的人群，以及目前和未来可能改善衰老心脏中功能失调的组织重塑的治疗策略。
