School of Life Sciences and Engineering, Foshan University, Foshan, China.
Key Laboratory of Zoonoses Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.
Transbound Emerg Dis. 2020 Nov;67(6):2307-2312. doi: 10.1111/tbed.13629. Epub 2020 Jun 1.
In recent years, rabies virus (RABV) has been detected in numerous specific wild fur animals in northern China. Therefore, we performed an epidemiologic investigation of RABV in the main fur animal farming provinces during 2017-2019. The results showed that brain tissue samples from eight animals that presented with central nervous symptoms were positive for rabies virus according to direct fluorescent antibody assays and RT-PCR. The phylogenetic relationships and distributions of the viruses were determined, and the results indicated that they belonged to Cosmopolitan and Arctic-related lineages. Serological investigations revealed a RABV positivity rate of 2.78% (34/1,222) in fur animals. A total of 79 unimmunized breeders were negative for serum antibodies, and 9.62% of 52 immunized breeders (5/52) were not seroconverted. The results emphasize that specific wild fur animals are potential sources of RABV and that the current vaccination programme for animals and breeders is deficient, indicating the need for mandatory rabies vaccination to eliminate rabies transmission from dogs to farmed fur animals.
近年来，在中国北方的许多特定野生动物中检测到了狂犬病病毒（RABV）。因此，我们在 2017 年至 2019 年期间对主要毛皮动物养殖省份的 RABV 进行了流行病学调查。结果表明，根据直接荧光抗体检测和 RT-PCR，8 只出现中枢神经系统症状的动物的脑组织样本呈狂犬病病毒阳性。还确定了病毒的系统发育关系和分布，结果表明它们属于世界性和北极相关谱系。血清学调查显示，毛皮动物的 RABV 阳性率为 2.78%（34/1,222）。总共 79 只未免疫的繁殖者血清抗体检测均为阴性，而 52 只免疫繁殖者中的 9.62%（5/52）未发生血清转化。结果强调了特定的野生动物是 RABV 的潜在来源，并且目前针对动物和繁殖者的疫苗接种计划存在缺陷，这表明需要强制接种狂犬病疫苗以消除从狗到养殖毛皮动物的狂犬病传播。
