Oyanagui Y, Sato S, Okajima T
Research Laboratories of Fujisawa Pharmaceutical Co., Osaka, Japan.
Free Radic Res Commun. 1988;4(6):385-96. doi: 10.3109/10715768809066906.
Various sources of superoxide dismutases (SOD) suppressed ischaemic paw oedemata (tourniquet poditis) of mice, rats and guinea pigs with different potencies. Intravenous (i.v.) dosing of mouse Cu,Zn-SOD had no effect on mouse ischaemic oedema, yet rat and guinea pig Cu,Zn-SOD suppressed ischaemic oedemata of rats and guinea pigs. Homologous SOD was anti-inflammatory at least in these two models. Guinea pig SOD was one of the most potent in all models, but showed a very narrow range of effective dose. This bell-shape suppressive pattern was ameliorated by concomitant catalase injection. Bovine and human Cu,Zn-SOD had a rather broad range of effective dose. Bacterial Mn-SODs were suppressive in mice, as well as the oxygen radical scavenger MK-447 and cytochrome c. Dexamethasone was effective only when administered more than 3 hrs in advance. As ischaemic paw oedema of mice was not sensitive to cyclooxygenase and lipoxygenase inhibitors, this model could serve for screening new types of anti-inflammatory or anti-ischaemic drugs.
超氧化物歧化酶（SOD）的各种来源以不同效力抑制小鼠、大鼠和豚鼠的缺血性爪部水肿（止血带性足部炎症）。静脉注射（i.v.）小鼠铜锌超氧化物歧化酶对小鼠缺血性水肿无影响，但大鼠和豚鼠的铜锌超氧化物歧化酶可抑制大鼠和豚鼠的缺血性水肿。同源超氧化物歧化酶至少在这两种模型中具有抗炎作用。豚鼠超氧化物歧化酶在所有模型中是效力最强的之一，但有效剂量范围非常窄。这种钟形抑制模式可通过同时注射过氧化氢酶得到改善。牛和人铜锌超氧化物歧化酶的有效剂量范围相当宽。细菌锰超氧化物歧化酶在小鼠中具有抑制作用，氧自由基清除剂MK - 447和细胞色素c也有此作用。地塞米松仅在提前3小时以上给药时才有效。由于小鼠缺血性爪部水肿对环氧化酶和脂氧化酶抑制剂不敏感，该模型可用于筛选新型抗炎或抗缺血药物。
