生物分子高密度接枝刷状聚合物：寡核苷酸、寡糖和寡肽。
Biomolecular Densely Grafted Brush Polymers: Oligonucleotides, Oligosaccharides and Oligopeptides.
机构信息
Department Department of Chemistry, Materials Science & Engineering, Biomedical Engineering, Pharmacology, International Institute for Nanotechnology, Simpson Querrey Institute, Chemistry of Life Processes Institute, Lurie Cancer Center, Northwestern University, 2145 Sheridan Road, Evanston, Illinois, 60208, USA.
出版信息
Angew Chem Int Ed Engl. 2020 Nov 2;59(45):19762-19772. doi: 10.1002/anie.202005379. Epub 2020 Aug 28.
Abstract
In this Minireview, we describe synthetic polymers densely functionalized with sequence-defined biomolecular sidechains. We focus on synthetic brush polymers of oligonucleotides, oligosaccharides, and oligopeptides, prepared via graft-through polymerization from biomolecule functionalized monomers. The resulting structures are brush polymers wherein a biomolecular graft is positioned at each monomer backbone unit. We describe key synthetic milestones, identify synthetic opportunities, and highlight recent advances in the field, including biological applications.
摘要
在这篇综述中，我们描述了用序列定义的生物分子侧链密集官能化的合成聚合物。我们专注于通过从生物分子官能化单体进行接枝聚合制备的寡核苷酸、寡糖和寡肽的合成刷状聚合物。得到的结构是刷状聚合物，其中生物分子接枝位于每个单体主链单元上。我们描述了关键的合成里程碑，确定了合成机会，并强调了该领域的最新进展，包括生物应用。
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