Key Laboratory of Hebei Province for Molecular Biophysics, Institute of Biophysics, Hebei University of Technology, Tianjin, 300401, P. R. China.
Department of Life Science and Bioprocesses, Fraunhofer Institute for Applied Polymer Research IAP, Geiselbergstr. 69, 14476, Potsdam-Golm, Germany.
Angew Chem Int Ed Engl. 2021 May 10;60(20):11098-11103. doi: 10.1002/anie.202015692. Epub 2021 Mar 25.
Glyco-assemblies derived from amphiphilic sugar-decorated block copolymers (ASBCs) have emerged prominently due to their wide application, for example, in biomedicine and as drug carriers. However, to efficiently construct these glyco-assemblies is still a challenge. Herein, we report an efficient technology for the synthesis of glyco-inside nano-assemblies by utilizing RAFT polymerization of a galactose-decorated methacrylate for polymerization-induced self-assembly (PISA). Using this approach, a series of highly ordered glyco-inside nano-assemblies containing intermediate morphologies were fabricated by adjusting the length of the hydrophobic glycoblock and the polymerization solids content. A specific morphology of complex vesicles was captured during the PISA process and the formation mechanism is explained by the morphology of its precursor and intermediate. Thus, this method establishes a powerful route to fabricate glyco-assemblies with tunable morphologies and variable sizes, which is significant to enable the large-scale fabrication and wide application of glyco-assemblies.
糖基组装体来源于两亲性糖修饰的嵌段共聚物（ASBC），由于其广泛的应用而受到关注，例如在生物医药和药物载体方面。然而，高效地构建这些糖基组装体仍然是一个挑战。在此，我们报告了一种利用半乳糖修饰的甲基丙烯酸酯的 RAFT 聚合进行聚合诱导自组装（PISA）来合成糖基内纳米组装体的有效技术。通过这种方法，通过调整疏水性糖嵌段的长度和聚合固体含量，可以制备一系列具有中间形态的高度有序的糖基内纳米组装体。在 PISA 过程中捕获了一种复杂囊泡的特定形态，并且通过其前体和中间体的形态解释了其形成机制。因此，该方法建立了一种制备具有可调形态和可变尺寸的糖组装体的有力途径，这对于实现糖组装体的大规模制备和广泛应用具有重要意义。
