Mertoğlu Cuma, Gunay Murat, Siranli Gulsah, Kulhan Mehmet, Gok Gamze, Erel Özcan
a Department of Clinical Biochemistry , Faculty of Medicine, Erzincan University , Erzincan , Turkey.
b Department of Obstetrics and Gynecology , Faculty of Medicine, Erzincan University , Erzincan , Turkey.
Fetal Pediatr Pathol. 2018 Jun;37(3):147-156. doi: 10.1080/15513815.2018.1453002. Epub 2018 Apr 25.
A 50 g glucose challenge test (GCT) is recommended for screening all pregnant women for gestational diabetes mellitus. In this study, the effect of GCT on the thiol/disulfide balance was investigated.
One-hundred women that underwent a 50 g GCT at 24-28 weeks of gestation (63 positive and 37 negative results) were evaluated in terms of thiol/disulfide in serum samples at test hours 0 and 1.
Compared to the baseline values (hour 0), after the glucose load (hour 1), the thiol and native thiol/total thiol (p < 0.0001) of the GCT-positive women were reduced whereas the values of glucose, disulfide, disulfide/native thiol, disulfide/total thiol (p < 0.0001) and total thiol increased (p = 0.018).
In GCT-positive pregnant individuals, the glucose load increases oxidative stress by changing the thiol/disulfide homeostasis. Such an effect is not observed in healthy pregnancies.
推荐对所有孕妇进行50克葡萄糖耐量试验（GCT）以筛查妊娠期糖尿病。本研究调查了GCT对硫醇/二硫化物平衡的影响。
对100名在妊娠24 - 28周时接受50克GCT的女性（63例结果为阳性，37例结果为阴性）在测试时间0小时和1小时时的血清样本中的硫醇/二硫化物进行评估。
与基线值（0小时）相比，葡萄糖负荷后（1小时），GCT阳性女性的硫醇和天然硫醇/总硫醇（p < 0.0001）降低，而葡萄糖、二硫化物、二硫化物/天然硫醇、二硫化物/总硫醇（p < 0.0001）和总硫醇的值升高（p = 0.018）。
在GCT阳性的孕妇中，葡萄糖负荷通过改变硫醇/二硫化物内环境稳态增加氧化应激。在健康妊娠中未观察到这种效应。
