Mohammadi Mohaddeseh, Khodarahmi Mahdieh, Kahroba Houman, Farhangi Mahdieh Abbasalizad
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Eat Weight Disord. 2020 Oct;25(5):1447-1459. doi: 10.1007/s40519-020-00855-1. Epub 2020 Feb 3.
Evidence shows the role of polymorphisms in rs17782313 MC4R gene with increased risk of obesity in Asians adult. In the current report, we investigated the interaction between rs17782313 MC4R gene and major dietary patterns on α-melanocyte stimulating hormone (α-MSH), Agouti-related peptide (AgRP), serum lipids and blood pressure among obese individuals.
This cross-sectional study was performed in 288 obese adults between 20 and 50 years of age. Anthropometric measurements and biochemical assays were conducted with standard methods. To evaluate appetite, the Visual Analogue Scale (VAS) was used. Dietary patterns were obtained by principal component analysis (PCA). Genotyping of rs17782313 was assessed by restriction fragment length polymorphism (PCR-RFLP) method.
Three major dietary patterns were extracted: Prudent Dietary Pattern (PDP), Legume Dietary Pattern (LDP) and Mixed Dietary Pattern (MDP). Higher PDP score was associated with reduced SBP and insulin concentration while highest MDP score was associated with lower TG concentration (P < 0.05). Significant interactions were observed between higher adherence to PDP and rs17782313 CC genotype on increased SBP (P = 0.04), serum insulin (P = 0.05) and AgRP (P = 0.03) and also between higher adherence to MDP and CC genotype of rs17782313 on reduced serum TG (P = 0.03).
The findings of the current study showed that being on CC genotype of rs17782313 polymorphism made obese individuals more prone to have higher SBP, insulin and AgRP even in highest adherence to PDP. However, adherence to MDP could attenuate the risky effects of being on CC genotype of rs17782313 by reducing serum TG concentrations.
Level V, cross-sectional descriptive study.
有证据表明，rs17782313 MC4R基因多态性与亚洲成年人肥胖风险增加有关。在本报告中，我们研究了rs17782313 MC4R基因与主要饮食模式对肥胖个体中α-黑素细胞刺激素（α-MSH）、刺鼠相关肽（AgRP）、血脂和血压的相互作用。
本横断面研究对288名20至50岁的肥胖成年人进行。采用标准方法进行人体测量和生化检测。使用视觉模拟量表（VAS）评估食欲。通过主成分分析（PCA）获得饮食模式。采用限制性片段长度多态性（PCR-RFLP）方法对rs17782313进行基因分型。
提取出三种主要饮食模式：谨慎饮食模式（PDP）、豆类饮食模式（LDP）和混合饮食模式（MDP）。较高的PDP得分与收缩压和胰岛素浓度降低相关，而最高的MDP得分与较低的甘油三酯浓度相关（P<0.05）。观察到较高的PDP依从性与rs17782313 CC基因型之间在收缩压升高（P=0.04）、血清胰岛素（P=0.05）和AgRP（P=0.03）方面存在显著相互作用，以及较高的MDP依从性与rs17782313 CC基因型之间在血清甘油三酯降低（P=0.03）方面存在显著相互作用。
本研究结果表明，即使在最高的PDP依从性下，rs17782313多态性的CC基因型也会使肥胖个体更容易出现较高的收缩压、胰岛素和AgRP。然而，坚持MDP可以通过降低血清甘油三酯浓度来减弱rs17782313 CC基因型的风险效应。
V级，横断面描述性研究。
