Ochsendorf F R, Schöfer H, Runne U, Milbradt R
Zentrum der Dermatologie und Venerologie, Klinikum der J.W. Goethe-Universität Frankfurt/Main.
Hautarzt. 1988 Nov;39(11):736-8.
Oral hairy leukoplakia was treated in six patients with (a) acyclovir (i.v. or p.o.), (b) 0.1% vitamin-A acid solution or (c) human beta-interferon-gel (10(5) I.E./g) in a total of 23 therapeutic courses. In 5/6 patients, acyclovir (7.5 mg/kg every 8 h i.v. or 5 x 400 mg p.o. over 5-10 days) led to partial (n = 1) or complete (n = 4) remission. After 1-6 months, however, the leukoplakia recurred in all cases. Vitamin-A acid solution (n = 3) led to remission in one and to improvement in the others. Human beta-interferon gel (n = 3) had no visible effect. The efficacy of acyclovir is further evidence of the concept that the Epstein-Barr virus is a major cause of oral hairy leukoplakia.
对6例口腔毛状白斑患者进行了治疗，共进行了23个疗程，治疗方法分别为：(a) 阿昔洛韦（静脉注射或口服）、(b) 0.1%维甲酸溶液或(c) 人β-干扰素凝胶（10⁵国际单位/克）。在6例患者中的5例中，阿昔洛韦（静脉注射每8小时7.5毫克/千克或口服5天至10天，每天5次，每次400毫克）导致部分缓解（1例）或完全缓解（4例）。然而，1至6个月后，所有病例的白斑均复发。维甲酸溶液（3例）使1例缓解，其他病例病情改善。人β-干扰素凝胶（3例）未见明显效果。阿昔洛韦的疗效进一步证明了爱泼斯坦-巴尔病毒是口腔毛状白斑主要病因这一观点。
