Avesta Leli, Doustkami Hossein, Zamani Bijan, Nejati Afshin, Mousavy Sajad, Aslani Mohammad Reza
Department of Cardiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
ARYA Atheroscler. 2022 Jul;18(4):1-10. doi: 10.48305/arya.v18i0.2262.
Elevated serum visfatin levels have been reported in some chronic inflammatory diseases such as cardiovascular diseases (CVDs) and rheumatoid arthritis. The purpose of the present study was to investigate the correlation between visfatin and interleukin-6 (IL-6) and anthropometric, angiographic, echocardiographic, and biochemical parameters in patients with acute myocardial infarction (AMI).
In this case-control study, 90 patients who were candidates for angiography were divided into the following 3 groups: non-coronary artery disease group (non-CAD; n = 30) with a history of chest pain without angiographic changes, stable angina pectoris group (SAP; n = 30), and AMI group (n = 30). Anthropometric, angiographic, echocardiographic, and biochemical parameters were measured in all subjects.
The mean age of patients in the non-CAD, SAP, and AMI groups was 62.26 ± 13.24, 62.93 ± 8.35, and 52.83 ± 10.26 years (P < 0.001) respectively. The results showed that the median [interquartile range] of visfatin level was higher in the AMI group [7 (6.30-9.30), pg/ml] compared with the SAP [5.85 (5.20-6.60); P < 0.001] and non-CAD [5.20 (3.30-5.70); P < 0.001] groups. In addition, median [interquartile range] IL-6 levels were higher in the AMI group [17.5 (16-21), pg/ml] compared with the SAP [15.50 (14-18); P < 0.01] and non-CAD [14 (11-17); P < 0.001] groups. Furthermore, there was a positive association between plasma level of visfatin, and epicardial fat thickness (EFT) and the Gensini score in the SAP and AMI patients. The results of multivariate linear regression analysis revealed that white blood cell ý(WBC) count and IL-6 were independently associated with plasma visfatin level.
The current study showed an association between visfatin and EFT in AMI patients. Increased visfatin levels in patients with AMI may contribute to atherosclerosis; however, further studies should be conducted to confirm this finding.
在一些慢性炎症性疾病如心血管疾病（CVD）和类风湿关节炎中，血清内脂素水平升高已有报道。本研究的目的是探讨急性心肌梗死（AMI）患者体内内脂素与白细胞介素-6（IL-6）以及人体测量学、血管造影、超声心动图和生化参数之间的相关性。
在这项病例对照研究中，90名接受血管造影的患者被分为以下3组：无冠状动脉疾病组（非CAD；n = 30），有胸痛病史但血管造影无变化；稳定型心绞痛组（SAP；n = 30）；AMI组（n = 30）。测量了所有受试者的人体测量学、血管造影、超声心动图和生化参数。
非CAD组、SAP组和AMI组患者的平均年龄分别为62.26±13.24岁、62.93±8.35岁和52.83±10.26岁（P < 0.001）。结果显示，AMI组内脂素水平的中位数[四分位间距]高于SAP组[5.85（5.20 - 6.60）；P < 0.001]和非CAD组[5.20（3.30 - 5.70）；P < 0.001]，分别为7（6.30 - 9.30）pg/ml。此外，AMI组IL-6水平的中位数[四分位间距]也高于SAP组[15.50（14 - 18）；P < 0.01]和非CAD组[14（11 - 17）；P < 0.001]，分别为17.5（16 - 21）pg/ml。此外，在SAP组和AMI组患者中，内脂素血浆水平与心外膜脂肪厚度（EFT）和Gensini评分之间存在正相关。多元线性回归分析结果显示，白细胞计数（WBC）和IL-6与血浆内脂素水平独立相关。
本研究表明AMI患者体内内脂素与EFT之间存在关联。AMI患者内脂素水平升高可能促进动脉粥样硬化；然而，需要进一步研究来证实这一发现。
