入院时血脂谱及其相对比值（胆固醇/高密度脂蛋白胆固醇、甘油三酯/高密度脂蛋白胆固醇、低密度脂蛋白胆固醇/高密度脂蛋白胆固醇、白细胞/高密度脂蛋白胆固醇和空腹血糖/高密度脂蛋白胆固醇）对预测 COVID-19 患者院内死亡率的作用
Role of Lipid Profile and Its Relative Ratios (Cholesterol/HDL-C, Triglyceride/HDL-C, LDL-C/HDL-C, WBC/HDL-C, and FBG/HDL-C) on Admission Predicts In-Hospital Mortality COVID-19.
作者信息
Mohammadshahi Jafar, Ghobadi Hassan, Matinfar Golchin, Boskabady Mohammad Hossein, Aslani Mohammad Reza
机构信息
Department of Infectious Diseases and Tropical Medicine, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
Lung Diseases Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.
出版信息
J Lipids. 2023 Mar 6;2023:6329873. doi: 10.1155/2023/6329873. eCollection 2023.
BACKGROUND
Lipid profile and its related ratios such as total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), TG/HDL-C ratio, TC/HDL-C ratio, LDL-C/HDL-C ratio, white blood cell (WBC)/HDL-C ratio, and fasting blood glucose (FBG)/HDL-C ratio are valuable indicators that have been studied in various disorders to predict mortality. The present study was conducted with the aim of investigating the role of lipid profile ratios in predicting mortality in COVID-19 patients.
METHODS
At the beginning of hospitalization, laboratory tests were taken from all patients ( = 300). The ability of lipid profile ratios to determine the COVID-19 severity was evaluated using receiver-operating characteristic (ROC). In addition, survival probability was determined with the average of Kaplan-Meier curves, so that the end point was death.
RESULTS
In deceased patients, TG, TC, LDL-C, HDL-C, TC/HDL-C, TG/HDL-C, and LDL-C/HDL-C parameters were significantly lower than those of surviving patients, while WBC/HDL-C and FBG/HDL-C were significantly higher. TC (HR = 3.178, 95%CI = 1.064 to 9.491, < 0.05), TG (HR = 3.276, 95%CI = 1.111 to 9.655, < 0.05), LDL-C (HR = 3.207, 95%CI = 1.104 to 9.316, < 0.05), and HDL-C (HR = 3.690, 95%CI = 1.290 to 10.554, < 0.05), as well as TC/HDL-C (HR = 3.860, 95%CI = 1.289 to 11.558, < 0.05), TG/HDL-C (HR = 3.860, 95%CI = 1.289 to 11.558, < 0.05), LDL-C/HDL-C (HR = 3.915, 95%CI = 1.305 to 11.739, < 0.05), WBC/HDL-C (HR = 3.232, 95%CI = 1.176 to 8.885, < 0.05), and FBG/HDL-C ratios (HR = 4.474, 95%CI = 1.567 to 12.777, < 0.01), were detectably related to survival. The multivariate Cox regression models showed that only FBG/HDL-C ratio (HR = 5.477, 95%CI = 1.488 to 20.153, < 0.01) was significantly related to survival.
CONCLUSION
The results suggested that FBG/HDL-C ratio in hospital-admitted COVID-19 patients was a reliable predictor of mortality.
背景
血脂谱及其相关比值，如总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、TG/HDL-C比值、TC/HDL-C比值、LDL-C/HDL-C比值、白细胞（WBC）/HDL-C比值和空腹血糖（FBG）/HDL-C比值，是在各种疾病中用于预测死亡率的重要指标。本研究旨在探讨血脂谱比值在预测COVID-19患者死亡率中的作用。
方法
在住院初期，对所有患者（n = 300）进行实验室检查。使用受试者工作特征（ROC）曲线评估血脂谱比值确定COVID-19严重程度的能力。此外，通过Kaplan-Meier曲线的平均值确定生存概率，终点为死亡。
结果
死亡患者的TG、TC、LDL-C、HDL-C、TC/HDL-C、TG/HDL-C和LDL-C/HDL-C参数显著低于存活患者，而WBC/HDL-C和FBG/HDL-C显著高于存活患者。TC（HR = 3.178，95%CI = 1.064至9.491，P < 0.05）、TG（HR = 3.276，95%CI = 1.111至9.655，P < 0.05）、LDL-C（HR = 3.207，95%CI = 1.104至9.316，P < 0.05）、HDL-C（HR = 3.690，95%CI = 1.290至10.554，P < 0.05），以及TC/HDL-C（HR = 3.860，95%CI = 1.289至11.558，P < 0.05）、TG/HDL-C（HR = 3.860，95%CI = 1.289至11.558，P < 0.05）、LDL-C/HDL-C（HR = 3.915，95%CI = 1.305至11.739，P < 0.05）、WBC/HDL-C（HR = 3.232，95%CI = 1.176至8.885，P < 0.05）和FBG/HDL-C比值（HR = 4.474，95%CI = 1.567至12.777，P < 0.01）与生存显著相关。多因素Cox回归模型显示，只有FBG/HDL-C比值（HR = 5.477，95%CI = 1.488至20.153，P < 0.01）与生存显著相关。
结论
结果表明，住院COVID-19患者的FBG/HDL-C比值是死亡率的可靠预测指标。
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