Morozova E Ia
Antibiotiki. 1977;22(2):165-8.
In development of experimental melioidosis intoxication, the activity of the mechanisms controlling non-specific immunological reactions changed that was evident from changes both in the quantitative and qualitative indices of phagocytosis. The absorption function of the neutrophils was lowered during 2 days from the moment of administration of acetone killed bacterial mass of the melioidosis causative agent which was evident from decreased percentage and index of phagocytosis as compared to the control animals. The qualitative index of the digestive capacity of the neutrophils, i.e. the index of phagocytosis completeness was also low for 7 days of the experiment. The positive role of prodiglozan in activation of the host protective forces in cases with meliodosis intoxication was shown. Prodigizan administered 48 hours before injection of the bacterial mass of the melioidosis causative agent stimulated both the absorption and digestive capacities of the neutrophils.
在实验性类鼻疽中毒的发展过程中，控制非特异性免疫反应的机制活性发生了变化，这从吞噬作用的定量和定性指标的变化中明显可见。自给予类鼻疽病原体丙酮灭活菌团之时起的2天内，中性粒细胞的吞噬功能降低，与对照动物相比，吞噬百分比和吞噬指数降低即表明了这一点。在实验的7天内，中性粒细胞消化能力的定性指标，即吞噬完整性指数也较低。已表明丙二醇唑在类鼻疽中毒病例中激活宿主保护力方面具有积极作用。在注射类鼻疽病原体菌团前48小时给予丙二醇唑，可刺激中性粒细胞的吞噬和消化能力。
