Kim Han Byul, Kim Mi Kyung, Kim El, Ahn Keun Soo, Kim Hye Soon, Kim Nam Kyung
Division of Endocrinology and Metabolism, Department of Internal Medicine, Raphael Hospital, Daegu, Korea.
Division of Endocrinology and Metabolism, Department of Internal Medicine, Keimyung University Dongsan Hospital, Daegu, Korea.
Yeungnam Univ J Med. 2021 Jan;38(1):60-64. doi: 10.12701/yujm.2020.00290. Epub 2020 May 22.
Cushing syndrome (CS) is rare in pregnancy, and few cases have been reported to date. Women with untreated CS rarely become pregnant because of the ovulatory dysfunction induced by hypercortisolism. It is difficult to diagnose CS in pregnancy because of its very low incidence, the overlap between the clinical signs of hypercortisolism and the physiological changes that occur during pregnancy and the changes in hypothalamus-pituitary-adrenal axis activity that occur during pregnancy and limit the value of standard diagnostic testing. However, CS in pregnancy is associated with poor maternal and fetal outcomes; therefore, its early diagnosis and treatment are important. Here, we report two patients with CS that was not diagnosed during pregnancy, in whom maternal and fetal morbidity developed because of hypercortisolism.
库欣综合征（CS）在妊娠期较为罕见，迄今为止仅有少数病例报道。未经治疗的CS女性因高皮质醇血症引起的排卵功能障碍很少怀孕。由于CS在妊娠期的发病率极低、高皮质醇血症的临床体征与孕期发生的生理变化存在重叠，以及孕期下丘脑-垂体-肾上腺轴活动的改变限制了标准诊断检测的价值，因此在妊娠期诊断CS较为困难。然而，妊娠期CS与母婴不良结局相关；因此，早期诊断和治疗至关重要。在此，我们报告两例妊娠期未被诊断出CS的患者，她们因高皮质醇血症出现了母婴发病情况。
