库欣综合征患者的妊娠问题。
Pregnancy in Patients with Cushing's Syndrome.
机构信息
Neuroendocrine Unit, Division of Endocrinology and Metabolism, Hospital das Clínicas, University of São Paulo Medical School, Avenida Enéas de Carvalho Aguiar, n° 155, 8° andar, bloco 03, São Paulo, São Paulo 05403-000, Brazil; Endocrinology Service, AC Camargo Cancer Center, Rua Prof. Antonio Prudente n° 211, São Paulo, SP 01509-010, Brazil; Laboratory for Endocrinology Cellular and Molecular - LIM25, University of São Paulo Medical School, Av. Dr. Arnaldo, 455, 4° andar, São Paulo, SP 01246-903, Brazil.
Neuroendocrine Unit, Division of Endocrinology and Metabolism, Hospital das Clínicas, University of São Paulo Medical School, Avenida Enéas de Carvalho Aguiar, n° 155, 8° andar, bloco 03, São Paulo, São Paulo 05403-000, Brazil.
出版信息
Endocrinol Metab Clin North Am. 2018 Jun;47(2):441-449. doi: 10.1016/j.ecl.2018.02.004.
Progress in diagnosis and treatment of endocrine diseases has made pregnancy possible for women with endocrinopathies, including Cushing's syndrome (CS). The risk of maternal-fetal complications in patients who are not biochemically controlled, however, is substantial. Therefore, the surgical and/or medical control of hypercortisolism is mandatory prior to conceiving. A diagnosis of de novo CS during gestation is difficult due to changes in the hypothalamic-pituitary-adrenal axis during pregnancy, which may lead to some clinical features suggestive of CS along with abnormal laboratory tests. This review presents the diagnosis and management of CS during pregnancy.
内分泌疾病的诊治进展使患有内分泌疾病（包括库欣综合征）的女性能够怀孕。然而，未通过生化控制的患者母婴并发症风险很大。因此，在怀孕前必须对皮质醇增多症进行手术和/或药物控制。由于妊娠期间下丘脑-垂体-肾上腺轴的变化，妊娠期间新发库欣综合征的诊断较为困难，这可能导致一些提示库欣综合征的临床特征以及实验室检查异常。本文综述了妊娠期间库欣综合征的诊断和治疗。
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