Gutmacher Ellay, Sárai Bálint Zsombor, Martineková Petrana, Kiss-Dala Szilvia, Agócs Gergely, Hegyi Péter, Bródy Andrea, Zsembery Ákos
Centre for Translational Medicine, Semmelweis University, Budapest, Hungary.
Department of Public Dental Health, Semmelweis University, Budapest, Hungary.
Sci Rep. 2025 Jul 10;15(1):24815. doi: 10.1038/s41598-025-07465-w.
Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer-related deaths. Early detection through non-invasive methods is critical for improving patient outcomes. This study investigates the association between the presence and relative abundance of Fusobacterium nucleatum (Fn) in saliva and CRC, evaluating its potential as a non-invasive biomarker. A systematic search was performed in MEDLINE, Embase, CENTRAL, and Scopus databases on November 25, 2023. Studies analyzing Fn in salivary samples from adults with CRC, colorectal polyps (CRP), or healthy individuals were included. Statistical analyses were performed using random-effects models to calculate pooled odds ratios (OR) and mean differences (MD) with 95% confidence intervals (CI). The risk of bias was assessed using the Quality in Prognosis Studies (QUIPS) tool. Of the 14,200 studies identified, twelve were included in our systematic review. Of these, eight were analyzed by meta-analysis. The results indicated no significant difference in the presence (OR 1.40; 95% CI [0.77; 2.54]; I = 0% [0; 71%], p = 0.215) or relative abundance (MD -0.01; 95% CI [-0.13; 0.11]; I = 25% [0; 69%], p = 0.851) of salivary Fn among CRC patients, compared to a combined group of CRP and healthy controls. Our findings suggest that the presence and relative abundance of salivary Fn are not associated with CRC.
结直肠癌（CRC）是全球第三大常见癌症，也是癌症相关死亡的第二大主要原因。通过非侵入性方法进行早期检测对于改善患者预后至关重要。本研究调查了唾液中具核梭杆菌（Fn）的存在及其相对丰度与结直肠癌之间的关联，评估其作为非侵入性生物标志物的潜力。于2023年11月25日在MEDLINE、Embase、CENTRAL和Scopus数据库中进行了系统检索。纳入了分析结直肠癌患者、结直肠息肉（CRP）患者或健康个体唾液样本中Fn的研究。使用随机效应模型进行统计分析，以计算合并优势比（OR）和平均差（MD）以及95%置信区间（CI）。使用预后研究质量（QUIPS）工具评估偏倚风险。在检索到的14200项研究中，有12项纳入了我们的系统评价。其中，8项进行了荟萃分析。结果表明，与CRP患者和健康对照的合并组相比，结直肠癌患者唾液中Fn的存在（OR 1.40；95%CI[0.77；2.54]；I=0%[0；71%]，p=0.215）或相对丰度（MD -0.01；95%CI[-0.13；0.11]；I=25%[0；69%]，p=0.851）无显著差异。我们的研究结果表明，唾液中Fn的存在及其相对丰度与结直肠癌无关。
