Department of Pediatrics, Division of Developmental Behavioral Pediatrics, Greenville Health System, 200 Patewood Drive, Suite A200, Greenville, SC 29615, USA.
University of South Carolina School of Medicine Greenville, 200 Patewood Drive, Greenville, SC 29615, USA.
Psychiatr Clin North Am. 2020 Jun;43(2):229-248. doi: 10.1016/j.psc.2020.02.004. Epub 2020 Apr 8.
The presence of heterotopias, increased regional density of neurons at the gray-white matter junction, and focal cortical dysplasias all suggest an abnormality of neuronal migration in autism spectrum disorder (ASD). The abnormality is borne from a dissonance in timing between radial and tangentially migrating neuroblasts to the developing cortical plate. The uncoupling of excitatory and inhibitory cortical cells disturbs the coordinated interactions of neurons within local networks, thus providing abnormal patterns of brainwave activity in the gamma bandwidth. In ASD, gamma oscillation abnormalities and autonomic markers offer measures of therapeutic progress and help in the identification of subgroups.
在自闭症谱系障碍（ASD）中，存在异位、灰质-白质交界处神经元区域密度增加和局灶性皮质发育不良，这些都表明神经元迁移异常。这种异常是由于放射状和切线迁移的神经母细胞到发育中的皮质板之间的时间不和谐引起的。兴奋性和抑制性皮质细胞的分离扰乱了局部网络中神经元的协调相互作用，从而在伽马频带中提供了异常的脑电波活动模式。在 ASD 中，伽马振荡异常和自主标记物提供了治疗进展的衡量标准，并有助于识别亚组。
